A tumor-homing peptide, F3, selectively binds to endothelial cells in tumor blood vessels and to tumor cells. Here, we show that the cell surface molecule recognized by F3 is nucleolin. Nucleolin specifically bound to an F3 peptide affinity matrix from extracts of cultured breast carcinoma cells. Antibodies and cell surface biotin labeling revealed nucleolin at the surface of actively growing c...

Most patients with non-small cell lung cancer (NSCLC) harboring common epidermal growth factor receptor (EGFR) mutations, such as deletions in exon 19 or the L858R mutation in exon 21, respond dramatically to EGFR tyrosine kinase inhibitors (EGFR-TKI), and their sensitivities to various EGFR-TKI have been well characterized. Our previous article showed the in vitro sensitivities of EGFR exon 18...

We explore the potential of ultimate unification Standard Model matter and gauge sectors into a single E8 superfield in ten dimensions via an intermediate Pati–Salam theory. Through consistent realisation T6/(Z6×Z2×Z2) orbifolding procedure renormalisation group evolution couplings, we establish several novel benchmark scenarios for New Physics that are worth further phenomenological exploration.

Let M be a complete, finite-volume, orientable hyperbolic manifold having exactly one cusp. If we assume that π1(M) has no subgroup isomorphic to a genus-2 surface group, and that either (a) dimZp H1(M ;Zp) ≥ 5 for some prime p, or (b) dimZ2 H1(M ;Z2) ≥ 4, and the subspace of H(M ;Z2) spanned by the image of the cup product H (M ;Z2) × H(M ;Z2) → H(M ;Z2) has dimension at most 1, then volM > 5....

Let M be a complete, finite-volume, orientable hyperbolic manifold having exactly one cusp. If we assume that π1(M) has no subgroup isomorphic to a genus-2 surface group, and that either (a) dimZp H1(M ;Zp) ≥ 5 for some prime p, or (b) dimZ2 H1(M ;Z2) ≥ 4, and the subspace of H(M ;Z2) spanned by the image of the cup product H(M ;Z2) × H(M ;Z2) → H(M ;Z2) has dimension at most 1, then volM > 5.0...

This paper develops and implements a new algorithm for calculating wave trace invariants of a bounded plane domain around a periodic billiard orbit. The algorithm is based on a new expression for the localized wave trace as a special multiple oscillatory integral over the boundary, and on a Feynman diagrammatic analysis of the stationary phase expansion of the oscillatory integral. The algorith...

Introducing liquid-crystalline small-molecule donors (SMDs) into binary systems based on the strong intermolecular interactions of SMDs is a facile and effective strategy to tune active layer morphology improve performance organic solar cells (OSCs). Contrary conventional understanding, this research proposes new for ternary OSCs implicating that “weakly crystalline materials can also optimize ...

S. Bauer and M. Furuta defined a stable cohomotopy refinement of the Seiberg-Witten invariants. In this paper, we prove a vanishing theorem of Bauer-Furuta invariants for 4-manifolds with smooth Z2-actions. As an application, we give a constraint on smooth Z2-actions on homotopy K3#K3, and construct a nonsmoothable locally linear Z2-action on K3#K3. We also construct a nonsmoothable locally lin...

This paper investigates some possible actions ”à la Johnson” on the set with 2 elements, denoted by E , of Spinstructures which are interpreted as special Z2-coverings of a trivial S−fibration over a non-orientable surface Ng+1. The group acting is first a group of orthogonal isomorphisms of (H1(Ng+1;Z2), ·). A second approach is to consider the subspace of E (with 2 elements) coming from speci...