the objective of the present study was to develop floating microspheres of cefpodoxime proxetil in order to achieve an extended retention in the upper git, which may result in enhanced absorption and thereby improved bioavailability. the microspheres were prepared by non-aqueous solvent evaporation method using polymers such as hydroxyl propyl methyl cellulose (hpmc k 15 m), ethyl cellulose in ...

one small-scale double emulsion technique for incorporation of naja- naja oxiana venom into poly (lactide-co-glycolide) (plga) microspheres were developed and optimized. the effects of high speed homogenization on the double emulsion stability, microsphere size, entrapment efficiency and in vitro release of venom were studied. a stable double emulsion was verified by homogenization method. slow...

High-resolution transmission electron microscopy (HRTEM) employing focus-variation phase-reconstruction methods is used to image the atomic structure of grain boundaries in a silicon nitride ceramic at subangstrom resolution. Complementary energy-dispersive X-ray emission spectroscopy experiments revealed the presence of yttrium ions segregated to the 0.5–0.7-nm thin amorphous boundary layers t...

Arsenic contamination in drinking water has become an increasingly important issue due to its high toxicity to humans. The present study focuses on the development of the yttrium-based adsorbents, with basic yttrium carbonate (BYC), Ti-loaded basic yttrium carbonate (Ti-loaded BYC) and yttrium hydroxide prepared using a co-precipitation method. The Langmuir isotherm results confirmed the maximu...

High resolution yttrium-90 ((90)Y) imaging of post-radioembolization microsphere biodistribution may be achieved by conventional positron emission tomography with integrated computed tomography (PET/CT) scanners that have time-of-flight capability. However, reconstructed (90)Y PET/CT images have high background noise, making non-target activity detection technically challenging. This educationa...

M. Pracht, J. Edeline, L. Lenoir, M. Latournerie, H. Mesbah, O. Audrain, Y. Rolland, B. Clément, J. L. Raoul, E. Garin, and E. Boucher 1 Comprehensive Cancer Center Eugène Marquis, CS 44229, 35042 Rennes, France University of Rennes 1, 35043 Rennes, France 3 INSERM U-991 Liver Metabolisms and Cancer, 35033 Rennes, France Department of Digestive Oncology, Comprehensive Cancer Center Paoli Calmet...

UNLABELLED Differences in maximum tolerable absorbed dose to normal liver between (90)Y radioembolization and external-beam radiation therapy have been explained by citing differences in absorbed-dose heterogeneity at the microscopic level. We investigated microscopic absorbed-dose heterogeneity in radioembolization as a function of the number of microspheres per unit volume in tumor. The goal ...

Porous hollow glass microspheres have many uses, including encapsulation of active materials. In this paper a fast and facile method for fabricating porous hollow glass-microspheres was demonstrated by etching them using dilute hydrofluoric acid. Then, a highly reactive amine was infiltrated into the etched glass microspheres. Scanning electron microscopy was conducted for the hollow glass micr...

BACKGROUND After yttrium-90 ((90)Y) microsphere radioembolization (RE), evaluation of extrahepatic activity and liver dosimetry is typically performed on (90)Y Bremsstrahlung SPECT images. Since these images demonstrate a low quantitative accuracy, (90)Y PET has been suggested as an alternative. The aim of this study is to quantitatively compare SPECT and state-of-the-art PET on the ability to ...

(90)Y PET/CT following radioembolization has recently been established as a viable diagnostic tool, capable of producing images that are both quantitative and have superior image quality than alternative (90)Y imaging modalities. Because radioembolization is assumed to be a permanent implant, it is possible to convert quantitative (90)Y PET image sets into data representative of spatial committ...