A high-throughput approach for biomolecule analysis is demonstrated for a mixture of peptides from tryptic digest of four proteins as well as a tryptic digests of human plasma. In this method a chip based electrospray autosampler coupled to a hybrid ion mobility (IMS) mass spectrometer (MS) is utilized to achieve rapid sample analysis. This high-throughput measurement is realized by exploiting ...

Dogs with compensated biventricular hypertrophy due to chronic atrioventricular block (cAVB), are more susceptible to develop drug-induced Torsade-de-Pointes arrhythmias and sudden cardiac death. It has been suggested that the increased Na(+) influx in hypertrophied cAVB ventricular myocytes contribute to these lethal arrhythmias. The increased Na(+) influx was not mediated by Na(+) channels, i...

BACKGROUND Nonalcoholic fatty liver disease (NAFLD) is one of the aspects of metabolic syndrome (MetS). Due to the increase of MetS in Iran, this study was conducted to determine the prevalence of NAFLD, its potential predictors and their sex distribution in north of Iran, Amol. METHODS In 2008 this population based cross-sectional study included 5023 adult individuals who were randomly selec...

Copper and arsenic underwent large changes in chemical form during the development and senescence of natural phytoplankton blooms in the Patuxent River, a subestuary ofChesapeake Bay in Maryland. Arsenate was rapidly reduced to arsenite and methylated species. At a total arsenic concentration of 20 nmollI , arsenate reduction rates ranged from 50 amol cellI d -I to > 230 amol cellI d -I, with t...

Ultrasensitive molecular beacon (MB) DNA biosensors, with micrometer to submicrometer sizes, have been developed for DNA/RNA analysis. The fluorescence-based biosensors have been applied in DNA/ RNA detection without the need for a dye-labeled target molecule or an intercalation reagent in the testing solution. Molecular beacons are hairpin-shaped oligonucleotides that report the presence of sp...

SUMMARY In order to survey goiter prevalence in mountainous villages of Arnot city (state of Mazandaran) I 76 boys and 157 girls were studied in Bayjan, Vana and Rineh. Goiter was present in 68 % , 71 % of girls and 65 % of boys. Dissemination of grades of goiter were: la 21.9%, lb 23.5%, II 18.6% and III 3. 6 % . There was an increase in the rate of large goiters with age. 50th percentile of...

We report here a unique approach to selectively label and detect specific RNA in an RNA mixture (without separation or purification) using DNA polymerase, dNTP labels, and a short synthetic DNA template complementary to the 3(')-terminus of the RNA. The detection sensitivity is high, at attomole level (10-18 mole). The selective principle was demonstrated by individually labeling and detecting ...

In the paper, it analyses the relationship between social capital and social security among the youth in sari(Northern Iran). Out of 65326 young people more than 118 ones were randomly selected through Cochran sampling method.The Alph- coranbach coefficient for the social capital were %85 and for social security were %83. According to Pearson correlation coefficient, there is a significant rela...

The aim of this research is to study altruism among the youth and is applied by the method of grounded theory. The focus of study is on exploring the social process which shapes altruism. The data were gathered through in-depth interviews 10 youth who lived in Mashhad. The results of the study highlight the complexity and variety of the youth experiences altruism that is a process reflects inte...