The substituted 1,2-dithiole-3-thione oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione] protects against the acute and chronic toxicities of many xenobiotics, including aflatoxin B1, in rodents. These protective effects are mediated, in part, through elevation of glutathione S-transferase (GST) activities. Because studies by Coles et al. [Carcinogenesis (Lond.), 6: 693-697, 1985] sugges...

Cheng-Der Fuh Graduate Institute of Statistics, National Central University, Jhong-Li and Institute of Statistical Science, Academia Sinica, Taipei, [email protected] Inchi Hu Department of ISOM, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, [email protected] Ya-Hui Hsu Abbott Laboratories, USA, [email protected] Ren-Her Wang Department of Banking...

A technique for deciding between two processes, one with cost (xA ,yA) and the second with cost (xB ,yB) where xA>xB and yA<yB and no further information is available, is derived, using dimensionand gauge-theory like arguments. The technique can be summarized as: If you can’t add them, multiply them.

Objectives Among older adults (OA), hearing loss is associated with an increased risk for falls. The aim of the present study was to experimentally investigate the cognitive compensation hypothesis, wherein decreased auditory and motor functioning are compensated by the recruitment of cognitive resources. Method Twenty-nine younger adults (YA), 26 OA, and 32 OA with age-related hearing loss (...

The CCAAT-binding protein NF-Y is involved in the regulation of a variety of eukaryotic genes and is formed in higher eukaryotes by three subunits NF-YA/B/C. We have characterized NF-Y of the trematode parasite Schistosoma mansoni and studied the structure and the function of the SMNF-YA subunit. In this work, we present the cloning and sequence analysis of the B subunit of the parasite factor....

The tuberous sclerosis complex (TSC) is caused by defects in one of two tumor suppressor genes, TSC-1 or TSC-2. TSC-2 gene encodes tuberin, a protein involved in the pathogenesis of kidney tumors, both angiomyolipomas and renal cell carcinomas. On the other hand, mice-deficient in the DNA repair enzyme OGG1 spontaneously develop adenoma and carcinoma. Downregulation of tuberin results in a mark...