OBJECTIVES/HYPOTHESIS To determine the tolerability of xylitol mixed with water as a nasal irrigant and to evaluate whether xylitol nasal irrigation results in symptomatic improvement of subjects with chronic rhinosinusitis. STUDY DESIGN A prospective, randomized, double-blinded, controlled crossover pilot study. METHODS Twenty subjects were instructed to perform sequential 10-day courses o...

Temperature and aeration shifts were used to perturb steady-state continuous cultures to determine the effects of ethanol on xylose metabolism by Candida shehatae. The accumulation of ethanol exerted a delayed inhibitory effect on the specific rate of substrate utilization. A second effect was also observed in which the specific rate of xylitol production increased at the expense of the specifi...

sequence suggested that the enzyme belongs to the short-chain dehydrogenase!reductase family. Expression plasmids for the xith gene were constructed and used to produce recombinant strains of G. orvdans that had up to 11-fold greater XDH actiyity than the wildtype strain. When used in the pToduction of xylitol from D-arabitol under controlled aeration and pH conditions, the strain harboring the...

Editorial Xylitol research has been conducted since the early 70's; at the beginning of 2009 there were almost 500 PubMed-indexed papers on " xylitol and dental ". Xylitol research was initiated in Finland, but nowadays the majority of papers are published by non-Finnish authors. Xylitol studies have been criticized mainly by European researchers. This criticism is reflected for example in the ...

d-Arabitol was observed to be toxic to many laboratory strains of Escherichia coli K-12, and xylitol was found to be toxic to an existing E. coli C mutant strain. Fructose-specific components of the phosphoenolpyruvate:sugar phosphotransferase system are required for xylitol toxicity. Selection for xylitol resistance results in Fru(-) strains blocked in fructose phosphotransferase. Introduction...

An l-xylulose reductase identified from the genome sequence of the filamentous fungus Neurospora crassa was heterologously expressed in Escherichia coli as a His(6) tag fusion protein, purified, and characterized. The enzyme may be used in the production of xylitol from the major pentose components of hemicellulosic waste, d-xylose and l-arabinose.