We discuss the development of Built-In SelfTest (BIST) configurations that test all of the programmable logic and interconnect resources in the core of Xilinx 4000E, 4000XL/XLA and Spartan series Field Programmable Gate Arrays (FPGAs). While there has been prior work in BIST for these FPGAs, the fast-carry logic has not been addressed and only a small portion of the total interconnect resources...

Primary immune deficiency diseases arise due to heritable defects that often involve signaling molecules required for immune cell function. Typically, these genetic defects cause loss of gene function, resulting in primary immune deficiencies such as severe combined immune deficiency (SCID) and X-linked agammaglobulinemia (XLA); however, gain-of-function mutations may also promote immune defici...

Protein Z (PZ) is a 62 kDa vitamin K-dependent plasma protein that serves as a cofactor for the inhibition of factor Xa by protein Z-dependent protease inhibitor (ZPI). ZPI is a recently identified 72 kDa member of the serpin superfamily of proteinase inhibitors that contains a tyrosine at its reactive center. PZ circulates in plasma in a complex with ZPI. Inhibition of factor Xa by ZPI in the ...

Factor IX Chicago-2 and prothrombin Madrid were purified from patients with hemophilia B and congenital dysprothrombinemia. respectively. Each protein displays defects in zymogen activation secondary to the failure to cleave one of the sessile bonds whose cleavage is necessary for full coagulant activity. These proteins were isolated by immunoaffinity chromatography using conformation-specific ...

Single-phase perovskite solid solutions are formed across the entire (1 − x)Pb(Mg1/3Ta2/3)O3–xLa(Mg2/3Ta1/3)O3 (PLMT) pseudobinary system. Although as-sintered (1300°C, 3 h) samples with x ≤ 0.1 adopt a phase-separated, “PMN-type” microstructure comprising small (2–3 nm) ordered domains dispersed in a disordered matrix, extensive domain growth and complete order can be induced by extended therm...

Good’s syndrome is a relatively rare immunodeficiency condition that presents in the fourth or fifth decade of life and is defined by hypogammaglobulinemia in the setting of a thymoma. The humoral defect may be severe enough to cause an absence in B cells, with a consequent recurrence of sinopulmonary disease, chronic non-infectious diarrhea and opportunistic infections. The prognosis in patien...

Lissencephaly has been described in over 10 distinct malformation syndromes. Recently, we have recognized 5 children from four unrelated families with an almost identical disorder comprising lissencephaly with a posterior-to-anterior gradient and only moderate increase in thickness of the cortex, absent corpus callosum, neonatal-onset epilepsy, hypothalamic dysfunction including deficient tempe...

Human coagulation factor XI has been purified, and upon activation with Hageman factor fragments. was found to convert the fibrinolytic proenzyme plasminogen to plasmin. This proactivator activity was shown to be functionally and antigenically distinct from prekallikrein. When the gamma-globulin fractions of plasma deficient in Hageman factor, prekallikrein and factor Xl were isolated, factor-X...

A complete range of perovskite solid solutions can be formed in the (1 x)Ba(Mg1/3Nb2/3)O3–xLa(Mg2/ 3Nb1/3)O3 (BMN–LMN) pseudobinary system. While pure BMN adopts a 1:2 cation ordered structure, 1:1 ordered phases are stabilized for 0.05 ≤ x ≤ 1.0. Dark-field TEM images indicate that the La-doped solid solutions are comprised of large 1:1 ordered domains and no evidence was found for a phase-sep...

LetM be a matroid on ground set E. A subset l ⊆ E is called a line when r(l) ∈ {1, 2}. Given a set of lines L = {l1, . . . , lk} in M , a vector x ∈ RL+ is called a fractional matching when ∑ l∈L xla(F )l ≤ r(F ) for every flat F ofM . Here a(F )l is equal to 0 when l∩F = ∅, equal to 2 when l ⊆ F and equal to 1 otherwise. We refer to ∑ l∈L xl as the size of x. It was shown by Chang et al. that ...