Three cases of this extraordinary condition recently came under observation. The affection was first described by Moriz Kaposi and given the name of xeroderma pigmentosum*. A large number of other names have been given, examples of which are atrophoderma pigmentosum (Crocker), melanosis lenticularis progressiva (Pick), and lioderma cum melanosi et telangiectasia (Neisser). Since these names are...

This book is an atlas with descriptive letterpress of the cancerous and precancerous conditions of the skin, in the aetiology of which sunlight is supposed to play a part. The majority of the plates illustrate the features of rodent ulcers, but in addition chronic solar dermatitis, cutaneous horn and epithelioma are illustrated, whilst xeroderma pigmentosum is described but not illustrated. The...

Fusion between HeLa and fibroblasts from complementation group D xeroderma pigmentosum (XPD) followed by challenge with small doses of ultraviolet light (u.v.) results in the production of hybrid cells expressing either HeLa (HD1) or XPD-like (HD2) sensitivity to u.v. and related repair capacity. Assays used included unscheduled DNA synthesis (UDS), DNA break accumulation in the presence of inh...

A case of cystic foreign body giant cell granuloma is presented. The patient, nineteen years of age, known case of Xeroderma Pigmentosum, presented to the maxillofacial unite, Basrah General Hospital, Iraq, with slowly enlarging cervical cystic mass. Examination revealed cystic swelling in the mid-left side of the neck of six months duration. The mass was not tender and was immobile. Aspiration...

SUMMARY Two sibs with Cockayne's syndrome are described. The recognised cellular sensitivity to ultraviolet light is confirmed. The clinical features in the two children are described and comparisons are made with some forms of xeroderma pigmentosum, a condition in which there is progressive neurological degeneration and cellular sensitivity to ultraviolet irradiation. In 1936 Cockaynel describ...

Ten lymphoblastoid cell lines were established by Epstein-Barr virus-induced transformation directly from 0.04 to 0.15 ml of peripheral whole blood of one patient with xeroderma pigmentosum and four normal healthy adults. All these lines expressed B-lymphocyte characteristics. The advantages of this method are: (a) only a few drops of blood are required for establishing a permanent line; (b) da...

Xeroderma pigmentosum group G (XPG) recognizes and excises DNA damage on the 3' side during the DNA repair process. Previous studies indicated that XPG gene polymorphisms may associate with gastric cancer susceptibility, but results were inconsistent. We evaluated the association of five potentially functional XPG polymorphisms (rs2094258 C>T, rs751402 C>T, rs2296147 T>C, rs1047768 T>C, and rs8...

Xeroderma pigmentosum group C (XPC) protein is a sensor of helix-distorting DNA lesions, the function of which is to trigger the global genome repair (GGR) pathway. Previous studies demonstrated that XPC protein operates by detecting the single-stranded character of non-hydrogen-bonded bases opposing lesion sites. This mode of action is supported by structural analyses of the yeast Rad4 homolog...