Signal transduction by xenobiotics in fish has recently gained much attention. The better known transduction mechanisms are those elicited by organochlorines, organophosphates, carbamates and heavy metals. Organochlorines specifically bind to the membrane bound ouabain sensitive Na+-K+-ATPase affecting neural transmission while the organophosphates and carbamates bind specifically to the membra...

toxicants.3 Following the Seveso disaster in northern Italy in 1976, a remarkable increase in the proportion of girls was reported among offspring of heavily dioxin exposed men.4 Thus, the overarching question is not whether environmental chemicals may represent a hazard to male reproductive health, but how important this hazard at exposure levels found in the general population is in compariso...

Classically, immunotoxicology has been defined as the study of adverse effect on the immune system associated with exposure to environmental chemicals, pharmacologic agents, and biologicals. Although a multitude of immune system defects may occur, these can be generally categorized as immunomodulation (immune suppression or potentiation), hypersensitivity (i.e., allergy), and autoimmunity. We p...

Mantle, T. J., Mannervik, B. and Hayes, J. D., eds.), pp. 2 1 1-22 1, CRC Press, Boca Raton, FL Andersson, C., Mosialou, E., Weinander, R., Hebert, H. and Morgenstern, R. (1993) in Structure and Function of Glutathione Transferases (Tew, K. D., Pickett, C. B.. Mantle, T. J., Mannervik, B. and Hayes, J. D., eds.), pp. 109-1 16, CRC Press, Boca Raton, FL Nicholson, D. W (1993) in Structure and Fu...