Between-animal variability has frustrated many experimental studies in outbred animal models of human disease. Variability that arises from genetic heterozygosity can be minimized by use of experimental designs that match littermates (polyzygotic twins) across control and treatment groups. Poor breeding vigor has prevented use of this experimental design in the WHHL rabbit model of hyperlipidem...

OBJECTIVE To test the hypothesis that a novel weight loss approach that combined the fundamental components of professionally delivered behavioral weight loss (BWL) treatment with the existing Weight Watchers (WW) program would produce better weight losses than WW alone no differences were expected between the novel treatment and BWL alone. DESIGN AND METHODS Participants were 141 overweight ...

7 n 2  ≤ WW (G1) + WW (G2) + WW (G3) ≤ 2  n + 2 4  + n 2  + 4(n − 1). The corresponding extremal graphs are characterized. Published by Elsevier B.V.

Direct measurements of the trilinear gauge boson couplings by the CDF and DØ collaborations at Fermilab are reviewed. Limits on the anomalous couplings were obtained at a 95% CL from four diboson production processes: Wγ production with the subsequent W boson decay to eν or μν, WW production with both the W boson decaying to eν or μν, WW/WZ production with one of the gauge bosons decaying lepto...

BACKGROUND & AIMS Significant biological variation in macronutrient content of breast milk is an important barrier that needs to be overcome to meet nutritional needs of preterm infants. To analyze macronutrient content, commercial infrared milk analyzers have been proposed as efficient and practical tools in terms of efficiency and practicality. Since milk analyzers were originally developed f...

The fragment of Prp40p spanning its two WW domains bound to phosphorylated CTD of RNA Pol II efficiently, whereas the Rsp5p WW domain region had a capacity to interact with both the phosphor-WW domains are protein–protein interaction modules ylated and unphosphorylated CTD, showing a clear pref-that bind to short proline-rich motifs in proteins that erence for the latter (Wang et al., 1999; Cha...

Observations of surface deformation are essential for understanding a wide range of geophysical problems, including earthquakes, volcanoes, landslides, and glaciers. Current geodetic technologies, such as global positioning system (GPS), interferometric synthetic aperture radar (InSAR), borehole and laser strainmeters, are costly and limited in their temporal or spatial resolutions. Here we pre...

BACKGROUND To evaluate the relationships between Reichert Ocular Response Analyzer (ORA) parameters corneal hysteresis (CH) and corneal response factor (CRF) and ocular dimensions, age and intraocular pressure. METHODS Two hundred and twelve eyes of 212 participants with no ocular pathology had CH and CRF measured with the ORA. Intraocular pressure (IOP) was measured with the Dynamic Contour ...

WW domains are conserved protein motifs of 38-40 amino acids found in a broad spectrum of proteins. They mediate protein-protein interactions by binding proline-rich modules in ligands. A 10 amino acid proline-rich portion of the morphogenic protein, formin, is bound in vitro by both the WW domain of the formin-binding protein 11 (FBP11) and the SH3 domain of Abl. To explore whether the FBP11 W...