Alterations of calcium handling and other second messenger cascades including protein kinase C (PKC) and A (PKA) were suggested to be responsible for abnormal vascular function in spontaneously hypertensive rats (SHR). However, the relative contribution of these pathways to vasoconstriction is still not completely understood. We investigated the effect of Ro 31-8220 (PKC inhibitor) and H89 (PKA...

conclusions these data suggest that single bilateral microinjection of aβ (25-35) could impair memory and can be used as an ad model in wistar rats. results the results showed that aβ (25-35) significantly impaired both step-through latency and time in dark compartment in the passive avoidance task. background alzheimer's disease (ad) is the most common form of dementia that leads to neurotoxic...

the life table parameters of schizaphis graminum (rondani) (hemiptera: aphididae) on four commercial cultivars of wheat (kohdasht, pastor, tajan and zagros) were determined in laboratory conditions. fertility life table were constructed using age-specific survivorship (lx) and age-specific fecundity (mx) and subsequently analyzed using jackknife method and anova. there were significant differen...

The present study was performed to examine the relation between the gain of the baroreceptor reflex and the pathogenesis of hypertension in the spontaneously hypertensive rat. Spontaneously hypertensive or Wistar-Kyoto rats underwent either sinoaortic baroreceptor denervation or sham denervation at 28-35 days of age. Four months later these rats were chronically instrumented for measurements of...

It has been described that histone acetylation levels are decreased in several cellular and in vivo neurodegeneration models as well as in normal brain aging, although the impact of the aging process on histone deacetylases (HDAC) activity yet remains poorly understood. Therefore, our aim was to evaluate the effect of the aging process on HDAC activity in hippocampi and frontal cortices from 3 ...

Recent data have revealed biological and genetic variability in normotensive Wistar-Kyoto rats, which are considered to be the most appropriate control strain for spontaneously hypertensive rats. To investigate the possibility that angiotensin converting enzyme activity could be affected by this variability, we measured plasma and tissue (lung, heart, renal cortex, renal medulla, and adrenal gl...

The development of vitamin K deficiency, vitamin K requirement and warfarin susceptibility were studied in several types of warfarin-resistant .and non-resistant rat. Domesticated HW strain rats needed about 13 times as much vitamin Kl as did Wistar rats to maintain normal blood-clotting function, while HS strain rats were intermediate in this and in their susceptibility to warfarin. The vitami...

introduction: learning and memory deficits in some diseases are new subjects of research. bupropion, as dopamine and noradrenaline reuptake inhibitor and an antidepressant agent, has been previously shown to affect learning and memory processes. this study was designed to test the effect of intra-hippocompal bupropion injection on active avoidance learning task in rats. methods: adult male wist...

Aim: The current study investigated the anti-oxidant effects of vitamins on lead-induced reproductive toxicity in male wistar rats.
 Study Design: A total 48 Wistar rats divided into 6 groups 8 per group were used this study. Group 1 served as positive control and was given normal animal feed water ad libitum. 2 negative administered 10mg/kg body weight lead acetate (Pb) only, 3 with 200mg...