Human Par-4/PAWR is a about 40 kDa protein containing 340 amino acids. Rat Par-4 has 332 amino acids whereas mouse Par-4 has 333 amino acids. Par4/PAWR has two putative nuclear localization sequences in the N-terminal region and a leucine zipper domain and a nuclear export sequence in the C-terminal portion. There is a SAC domain (147-206 amino acids), selective for apoptosis induction in cance...

It is well known that many arc routing problems can be transformed into the Equality Generalized Traveling Salesman Problem (E-GTSP), which in turn can be transformed into a standard Asymmetric Traveling Salesman Problem (TSP). This opens up the possibility of solving arc routing problems using existing solvers for TSP. This paper evaluates the performance of the state-of-the art TSP solver Lin...

It has been known for many hundreds of years that asthma is worse at night. Sir John Floyer in his classic 'Treatise of the Asthma' (1698) wrote: 'I have observed the fit always to happen after Sleep in the Night when Nerves are filled with windy Spirits, and the heat of the bed has rarified the Spirits and Humours'. l Although these exacerbations are a well established clinical phenomenon, the...

Most livestock and poultry odors are generated by the anaerobic decomposition of livestock wastes such as manure (feces and urine), spilled feed, bedding materials, and wash water. Increased organic loading rates due to expanding animal numbers, slug loading, concentrated waste streams, and/or inadequate amounts of dilution water increase the potential for odor emissions from waste management s...

Mathematical model of forest fire was based on an analysis of known experimental data and using concept and methods from reactive media mechanics. In this paper the assignment and theoretical investigations of the problems of crown forest fire spread in windy condition were carried out. In this context, a study—mathematical modeling—of the conditions of forest fire spreading that would make it ...

© 2011 The Authors. doi: 10.2340/00015555-1081 Journal Compilation © 2011 Acta Dermato-Venereologica. ISSN 0001-5555 Cold panniculitis in horse riders, also known as horse rider’s pernio or equestrian panniculitis, is a rare phenomenon. Most published reports present only a few patients (1–5). Cold-induced pernio has also been reported in cyclists, motorists, milk-delivery men, golf-buggy drive...

The American Society of Clinical Oncology (ASCO) 2017 Annual Meeting was held again at the McCormick Convention Center in Chicago, IL, USA. Over 37,500 international physicians, nurses, researchers, and exhibitors descended on the Windy City from June 2nd, 2017 through June 6th, 2017. This year's ASCO presidential theme, “Making a Difference in Cancer Care with You,” embodied the principle of t...