Atherosclerosis of lower extremity is often accompanied by thrombosis and plaque injury. Currently, there a lack comprehensive hemodynamics study that combines platelet activation related to injury in atherosclerosis. Thus, we first analyze the mechanism further investigate effects stenosis hematocrit through hemodynamic results. An Euler–Euler method used for mixed fluid containing red blood c...

The mechanical load imposed by the systemic circulation to the left ventricle is an important determinant of normal and abnormal cardiovascular function. Left ventricular afterload is determined by complex time-varying phenomena, which affect pressure and flow patterns generated by the pumping ventricle. Left ventricular afterload is best described in terms of pressure-flow relations, allowing ...

For over a century, the behavior of the aorta and other large arteries has been described as passive elastic tubes in which no active contraction occurs in the smooth muscle wall. In response to pulsatile pressure changes, the vessels undergo a 'passive' elastic dilatation-contraction cycle, described as a "Windkessel" effect. However, Mangel and colleagues have presented evidence that is contr...

We present a robust and computationally efficient parameter estimation strategy for fluid-structure interaction problems. The method is based on a filtering algorithm restricted to the parameter space, known as the reduced-order unscented Kalman filter. It does not require any adjoint or tangent problems. In addition, it can easily be run in parallel, which is of great interest in fluid-structu...

The prevailing view of the behavior of the smooth muscle wall of large arteries is described by the Windkessel hypothesis, in which the wall does not actively contract in synchrony with the cardiac cycle. This hypothesis has predominated for well over a century. By contrast, several lines of evidence show that the smooth muscle wall of the aorta and other large arteries is capable of undergoing...

Aortic impedance, wave reflection magnitude, and compliance were measured in patients with Marfan's syndrome during diagnostic cardiac catheterization. Impedance and wave reflections were calculated from standard Fourier series analysis of ascending aorta micromanometer pressure and electromagnetic flow records. Compliance was estimated by a method recently proposed that uses the area under the...