PURPOSE A phase II study was conducted to evaluate the activity and safety of topotecan in pediatric patients with recurrent Wilms' tumor. PATIENTS AND METHODS Patients with favorable histology Wilms' tumor (FHWT) and recurrence after at least one salvage chemotherapy regimen or with anaplastic histology Wilms' tumor (AHWT) in first or subsequent recurrence were eligible. Patients were strati...

Nephroblastoma (Wilms tumor) is the most common primary malignant renal tumor in children. Rarely, it may present in the adult age group. This is a case report of a diagnosed case of a 29-yearold female presenting with right-sided flank pain and hematuria. Abdominal sonogram revealed a right renal mass measuring 1.55 × 1.88 × 1.62 cm on the lower pole of the right kidney. CT scan showed a 2.1 ×...

Only 4-6% of children with renal tumor show inferior vena caval or right atrial infiltration at presentation. Tumor emboli are even rarer, and so far, sudden death as the presenting symptom has only been described at presentation in Wilms' tumor in eight cases. We report a unique case of Wilms' tumor that presented with small pulmonary emboli and immediately after as that was diagnosed before d...

A 20-month-old female presented with a palpable abdominal mass. Imaging revealed bilateral renal masses and pulmonary nodules. The genetic evaluation identified de novo 540kb X-chromosome deletion involving GPC3, PHF6, HPRT1, highly skewed X-inactivation (100:0). This clinical picture was suggestive of Wilms’ tumor in the setting Simpson-Golabi-Behmel Syndrome.

Wilms tumor, a common childhood tumor of the kidney, is thought to arise from undifferentiated renal mesenchyme. Variable tumor histology and the identification of tumor subsets displaying different gene expression profiles suggest that tumors may arise at different stages of mesenchyme differentiation and that this ontogenic variability impacts tumor pathology, biology, and clinical outcome. T...

Human insulin-like growth factor II gene (IGF2) is overexpressed, and its imprinting is disrupted in many tumors, including Wilms' tumor. A transcript that is antisense to IGF2, IGF2-antisense (IGF2-AS), is transcribed from within IGF2 in a reverse orientation. This transcript is also maternally imprinted and overexpressed in Wilms' tumor. IGF2-AS was detected as a 2.2 kb mRNA in Hep 3B cells b...

Wilms' tumor in adults is rare, and no treatment guidelines have been established. Spinal cord compression has also been rarely reported in all age groups. In this case report, we present a 19-year-old adolescent with recurrent Wilms' tumor, a paraspinal dumbbell mass, metastatic involvement of the vertebral bodies, lung metastasis, and pregnancy. To our knowledge, this is the first report of a...

Wilms' tumor (WT) and neuroblastoma (NB), the two most common extra-cranial solid malignant tumors, are seldom seen together in the same patient. A 10-month girl presented with a right retroperitoneal mass. A preoperative diagnosis of Wilms' tumor (WT) was made. She was given preoperative chemotherapy followed by surgery. At surgery a renal mass (WT) and a suprarenal mass (neuroblastoma - NB) w...

Wilms' tumor is an uncommon neoplasm in adults. We report the clinical manifestations, complementary explorations, treatment, and results from 3 males aged 16, 21, and 22 years. Computed tomography commonly suggests the diagnosis. Despite its aggressive treatment, such as radical surgery, chemo- and radiotherapy, the prognosis is worse than in children.