نتایج جستجو برای: wexner
تعداد نتایج: 155 فیلتر نتایج به سال:
STAT3 iswell corroborated preclinically as a cancer therapeutic target, but tractable translational strategies for its blockade by small molecule inhibitors have remained elusive. In this study, we report the development of a novel class of bifunctional STAT3 inhibitors, based on conjugation of a diarylidenyl-piperidone (DAP) backbone to an N-hydroxypyrroline (–NOH) group, which exhibits minima...
Transesophageal echocardiography and cardiac computed tomography angiography are currently utilized for left atrial appendage closure (LAAC) planning. The advent of high-resolution magnetic resonance imaging (HR-CMR) now potentially allows adequate spatial resolution LAAC This study sought to assess preoperative HR-CMR with software-based sizing vs intraoperative TEE LAA thrombus exclusion prio...
Acinetobacter baumannii is listed in the Centers for Disease Control and Prevention’s (CDC) report “Antibiotic Resistance Threats in the United States, 2013” as 1 of 18 microorganisms whose threat level is “urgent,” “serious,” or “concerning” according to their current and projected health and economic impacts [1]. The A. baumannii threat level is ranked as “serious” and carries a warning that ...
Hans-Joachim Anders, Brad Rovin, David Jayne, Paul Brunetta, Rosanna Coppo, Anne Davidson, Satish Kumar Devarapu, Dick de Zeeuw, Jeremy Duffield, Dirk Eulberg, Alberto Fierro, Jürgen Floege, Steffen Frese, Loïc Guillevin, Stephen Holdsworth, Jeremy Hughes, Ralph Kettritz, Malte Kluger, Christian Krebs, Larissa Lapteva, Adeera Levin, Jinhua Li, Liz Lightstone, Matthias Mack, Ladan Mansouri, Step...
AIM Clinical evaluation of the safety and effectiveness of compression anastomosis with ColonRing™ for large-bowel end-to-end anastomosis for rectal cancer and explanation of the procedure and the device itself since this device is used for the first time in our clinic. MATERIAL AND METHODS In November, 2012, a team of surgeons from our clinic attended the Clinical practice workshop in Belgra...
Obstructed defecation syndrome (ODS) is clinically defined as a prolonged (more than 6 months) history of difficult rectal evacuation, including excessive straining, feeling of incomplete evacuation or inability to evacuate without digitation. It is usually related to a functional disorder and it occurs most exclusively in females. Many authors 1-4 have reported an incidence of enterocoele from...
A proper total mesorectal excision (TME) technique is paramount to the successful treatment of locally advanced rectal cancer irrespective of operative method, including open and minimally-invasive approaches. The use of minimally-invasive surgery is of growing interest for the treatment of rectal cancer. The results of a recent, multicenter, randomized COREAN trial and of the COlorectal cancer...
BACKGROUND For patients with complex care needs, engagement in disease management activities is critical. Chronic illnesses touch almost every person in the United States. The costs are real, personal, and pervasive. In response, patients often seek tools to help them manage their health. Patient portals, personal health records tethered to an electronic health record, show promise as tools tha...
Background Susac Syndrome (SS) is a rare autoimmune endotheliopathy that affects the brain, retina, and inner ear, characterized by clinical triad of encephalopathy, branch retinal artery occlusion (BRAO), sensorineural hearing loss (SNHL) [1] . Brain MRI, fluorescein angiogram (FA), audiometry help to establish diagnosis [2] The presentation SS often variable leading delay in diagnosis. Object...
In June 2022, the U.S. Preventive Services Task Force (USPSTF) updated its 2014 recommendations to state that, for most vitamin, mineral, and multivitamin supplements, there is not enough evidence recommend or against taking them prevent CVD cancer.However, strong show that two vitamins—vitamin E beta-carotene—should be taken these conditions.Studies suggest no benefit vitamin E, beta-carotene ...
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