DREAM (also known as K(+) channel interacting protein 3 and calsenilin) is a calcium binding protein and an active modulator of KV4 channels in neuronal cells as well as a novel Ca(2+)-regulated transcriptional modulator. DREAM has also been associated with the regulation of Alzheimer's disease through the prevention of presenilin-2 fragmentation. Many interactions of DREAM with its binding par...

Abstract Study question What are the intimate hygiene practices of women in IVF treatment and do they correlate with vaginal microbiota? Summary answer Hygiene practices, specific douching use soap significantly increased risk abnormal microbiota (AVM). is known already The normal acts as a defense system against infection. AVM molecularly defined dysbiosis, resembling bacterial vaginosis (BV) ...

The natural space environment continues to surprise us. We recently witnessed the quietest solar minimum in the past 100 years, casting huge uncertainties on our expectations for approach to Solar Maximum. The overall space environment is made up of many related but independent parts. The Dynamic Radiation Environment Assimilation Model (DREAM) focuses on the spacecraft charging environment. DR...

Many studies have investigated the effect of waking experience, e.g., pre-sleep stimuli, stress, major life events, traumata, on dream content and have supported the so-called continuity hypothesis of dreaming, i. e. waking experience is reflected in dreams (Overviews: 1-3). On the other hand, systematic research on the effects of drams on subsequent waking life is scarce, although a considerab...

OBJECTIVE Schizophrenia is a chronic psychotic disorder with unknown etiology that causes cognitive impairment, affecting thinking, behavior, social function, sleep and dream content. This study considered the dream content of patients with schizophrenia, siblings of patients with schizophrenia, patients with psychiatric diagnoses other than schizophrenia, and a group of healthy controls. The a...

Modelling transport and deposition of caesium and iodine from the Chernobyl accident using the DREAM model J. Brandt, J. H. Christensen, and L. M. Frohn National Environmental Research Institute, Department of Atmospheric Environment, Frederiksborgvej 399, P.O. Box 358, DK-4000 Roskilde, Denmark Received: 11 April 2002 – Accepted: 14 May 2002 – Published: 24 June 2002 Correspondence to: J. Bran...

Dream should be considered as a kind of cognitive ability that is formed parallel to other cognitive capabilities like language. On the other hand, multiple sclerosis (MS) is a complex disease that can involve different aspects of our cognition. Therefore, MS may influence patients' dreams. In fact, we do not know what the importance of dream is in MS, but further studies may introduce dream an...

Ultraviolet (UV) radiation is a major inducer of skin aging and accumulated exposure to UV radiation increases DNA damage in skin cells, including dermal fi broblasts. In the present study, we developed a novel DNA repair regulating material discovery (DREAM) system for the high-throughput screening and identifi cation of putative materials regulating DNA repair in skin cells. First, we establi...

BACKGROUND The transcriptional repressor DREAM (downstream regulatory element antagonist modulator) controls the expression of prodynorphin and has been involved in the modulation of endogenous responses to pain. To investigate the role of DREAM in central mechanisms of pain sensitization, we used a line of transgenic mice (L1) overexpressing a Ca(2+)- and cAMP-insensitive DREAM mutant in spina...