Abstract This study evaluates the forensic utility of 23 autosomal short tandem repeat markers in 400 samples from Kuwaiti population, which four (D10S1248, D22S1045, D2S441 and SE33) are reported for first time Kuwait. All were shown to exhibit no deviation Hardy–Weinberg equilibrium, nor any linkage disequilibrium between within loci, indicating that these loci inherited independently, their ...

The analysis of chromosomal polymorphism of paracentric inversions in anopheline mosquitoes has often been instrumental to the discovery of sibling species complexes and intraspecific genetic heterogeneities associated with incipient speciation processes. To investigate the population structure of Anopheles funestus Giles (Diptera: Culicidae), one of the three most important vectors of human ma...

OBJECTIVES Polymyositis (PM) and dermatomyositis (DM) form part of the idiopathic inflammatory myopathies (IIMs). The chemokine monocyte chemotactic protein-1 (MCP-1) is expressed at sites of the T cell inflammatory response in the IIMs. We thus investigate whether genetic markers in the MCP-1 gene confer disease susceptibility for the development of PM and DM. METHODS DNA samples were analys...

The future of genetic studies of complex human diseases will rely more and more on the epidemiologic association paradigm. The author proposes to scan the genome for disease-susceptibility gene(s) by testing for deviation from Hardy-Weinberg equilibrium in a gene bank of affected individuals. A power formula is presented, which is very accurate as revealed by Monte Carlo simulations. If the dis...

The acquired prion disease kuru was restricted to the Fore and neighbouring linguistic groups of the Papua New Guinea highlands and largely affected children and adult women. Oral history documents the onset of the epidemic in the early twentieth century, followed by a peak in the mid-twentieth century and subsequently a well-documented decline in frequency. In the context of these strong assoc...

Hardy-Weinberg equilibrium (HWE) is the state of the genotypic frequency of two alleles of one autosomal gene locus after one discrete generation of random mating in an indefinitely large population: if the alleles are A and a with frequencies p and q(=1-p), then the equilibrium gene frequencies are simply p and q and the equilibrium genotypic frequencies for AA, Aa and aa are p2, 2pq and q2. I...

BACKGROUND By a new concept called "phase diagram", we compare two commonly used genotype-based tests for case-control genetic analysis, one is a Cochran-Armitage trend test (CAT test at x=0.5, or CAT0.5) and another (called MAX2) is the maximization of two Chi-square test results: one from the two-by-two genotype count table that combines the baseline homozygotes and heterozygotes, and another...

Aims: This study was aimed to investigate the association between angiotensin-converting enzyme gene (ACE) polymorphisms (rs4291, rs4309, rs4343, rs4646994) and nonarteritic anterior ischemic optic neuropathy (NAION) risk. Methods: The method of polymerase chain reaction (PCR) was used to perform the genotyping of ACE polymorphisms between the case and control groups. The χ2 test was conduct to...

To test for genetic association between a marker and a complex disease using a case-control design, Cochran-Armitage trend tests (CATTs) and Pearson's chi-square test are often employed. Both tests are genotype-based. Song and Elston (Statist. Med. 2006; 25:105-126) introduced the Hardy-Weinberg disequilibrium trend test and combined it with CATT to test for association. Compared to using a sin...

The Han nationality is an ancient and populous people, different places in China may have their distinct group relationships. Luzhou area, as a crossroads of several provinces Southwest China, lacks autosomal short tandem repeat (STR) research population genetics research. In this study, 21 STR loci were evaluated 1959 Han-Chinese individuals from area. There was no substantial linkage disequil...