CONTEXT Although commercial weight loss programs provide treatment to millions of clients, their efficacy has not been evaluated in rigorous long-term trials. OBJECTIVE To compare weight loss and health benefits achieved and maintained through self-help weight loss vs with a structured commercial program. DESIGN AND SETTING A 2-year, multicenter randomized clinical trial with clinic visits ...

Population pharmacokinetic (PK) and exposure-response analyses of apixaban were performed using data from phase I-III studies to predict bleeding risks for patients receiving apixaban 2.5 mg b.i.d. after total knee or hip replacement (TKR, THR) surgery (N = 5,510). Renal function, age, gender, and body weight impacted apixaban exposure. Bleeding risk increased as a function of exposure. Predict...

studied previously. Individually penned Finnish Landrace and Yorkshire pigs (30 kg; n=70) were fed basal diet with no added betaine or choline, the basal diet supplemented with 250, 500 or 1000 mg/kg of betaine (Betafin r S1), or with a similar molar amount of choline (578, 1155 or 2310 mg/kg of choline chloride). The net energy content of the maizesoybean meal basal diet was diluted with oat h...

The objective of this study was to determine the effect of different forage to concentrate ratios for fattening of Lohi lambs. For this purpose, 75 lambs were randomly divided into 3 groups A, B and C, with 25 lambs in each group. Berseem fodder was supplemented with concentrate at different ratios (forage to concentrate) as 75:25, 50:50 and 25:75 and fed to groups A, B and C, respectively for ...

AIMS To evaluate fetal growth in relation to gestational weight gain in women with Type 2 diabetes. METHODS A retrospective cohort study of 142 consecutive pregnancies in 28 women of normal weight, 39 overweight women and 75 obese women with Type 2 diabetes (pre-pregnancy BMI < 25, 25-29.9, ≥ 30 kg/m2, respectively). Gestational weight gain was categorized as excessive (exceeding the US Insti...

The choice of injected dose of 18 F -FDG and acquisition time is important in obtaining consistently high-quality PET images. The aim of this study was to determine the optimal acquisition protocols based on patient weight for 3-dimensional lutetium oxyorthosilicate PET/CT. Methods: This study was a retrospective analysis of 76 patients ranging from 29 to101 kg who were injected with 228–395.2 ...

BACKGROUND The aim of this study was to evaluate the pharmacokinetics of lamivudine (3TC), stavudine (d4T) and nevirapine (NVP) in HIV-infected Malawian children receiving quartered tablet multiples of Triomune 40 (generic tablet [GT]) compared with individual generic liquid (GL) and trade liquid (TL). METHODS This was a prospective randomized three-way crossover study. Patients (8-<12 kg, 18...

Optimal nutrient management is critical for optimizing flowering, yield, quality and improving soil health. A key approach making chrysanthemum crop cultivation profitable balanced fertigation at the right time. This possible by through drip. The present study was designed in 2019–2021 a model floriculture center, Pantnagar, to investigate response of split application NPK drip on flowering att...

Objective: The effect of herbal medicine is more useful than synthetic medicines. The present research paper aims to show the effects of leaves extracts of Zizyphus Spina Christi (ZSC) on lipid profile, lipid peroxidation and activities of aminotransferase enzymes in streptozocin induced diabetic adult male rats. Materials and Methods: Fifty six male rats weighing 150-200 gm were included in t...

Objective--To study the effect of birth weight and body weight on blood pressure in late adolescence. Design--Analysis of data on weight, height, and blood pressure at age 17 of subjects from the Jerusalem perinatal study, according to their birth weight. Data for men and women were analysed separately. Setting--Jerusalem, Israel. Subjects--32,580 subjects (19,734 men and 12,846 women) born in ...