Anti-neutrophil cytoplasmic Abs (cANCAs) against conformational epitopes of proteinase 3 (PR3) are regarded as an important pathogenic marker in Wegener's granulomatosis (WG). Although the three-dimensional structure of PR3 is known, binding sites of mAbs and cANCAs have not been mapped to date. Competitive binding and biosensor experiments suggested the existence of four nonoverlapping areas o...

Background In 2006 Ozen et al proposed new diagnostic criteria for the classification of childhood vasculitides. The aim of this retrospective study was to describe the incidence of Wegener's Granulomatosis (WG), Polyarteritis Nodosa (PAN) and Takayasu Arteritis (TA) in Denmark during the period of 1976–1998. Furthermore, we wanted to classify them according to the Chapel Hill Classification Cr...

1 Department of Civil and Environmental Engineering, University of California, Irvine, Irvine, CA, USA, 2 Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA, 3 Department of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA, 4 Bermuda Institute of Ocean Sciences, St. George’s, Bermuda, 5 Ecosystems Center, Marine Biological Laborat...

Sarcoidosis of the upper respiratory tract (SURT) includes nasopharyngeal, laryngeal and tracheal disease. Documented SURT occurs in approximately 5% of patients, although upper airway symptoms are more common in patients with sarcoidosis. Wegener granulomatosis may have a similar appearance to SURT, but there are important differences in the manifestations of the disease locally as well as sys...

The astute clinician occasionally detects herald or concurrent signs of systemic disease in the mouth, perianal area or genitalia. Surgical pathologists are familiar with testicular lymphoma,1 while scrotal2 and vulval3 4 lymphoma are rare. Genital vasculitis may either be isolated or a part of systemic disease and occurs more usually in the testis or spermatic cord.5 Penile polyarteritis nodos...