The activity of excitatory neurons is controlled by a highly diverse population of inhibitory interneurons. These cells show a high level of physiological, morphological and neurochemical heterogeneity, and play highly specific roles in neuronal circuits. In the mammalian hippocampus, these are divided into 21 different subtypes of GABAergic interneurons based on their expression of different m...

In this study, we used combinations of Cas9 or nickase (Cas9n) and single gRNA (sgRNA) ribonucleoprotein (RNP) complexes with single-stranded oligonucleotides (ssODN) to induce homology-directed repair (HDR) in junctional epidermolysis bullosa (JEB) keratinocytes a pathogenic mutation exon 52 COL17A1. To assess the correction efficiency, treated patient were then analysed via next generation se...

The recent clinical cases of hand and composite tissue allotransplantation opened a new era in the practice of reconstructive surgery. Some have suggested that face (allo)transplantation could be the next step to benefit patients whose conditions cannot be addressed by conventional techniques of reconstructive surgery using autologous tissues. This article reviews the current status of science ...

T scientific investigation of mental experiences is enjoying a productive renaissance. Rebounding after decades of repression by behaviorism and reductionism, neuroscientists have joined psychologists and philosophers in seeking to learn what distinguishes conscious from nonconscious functioning of brains (1–6). But despite the well known power of a comparative approach to challenging biologica...

Interteaching is a new method of classroom instruction that is based on behavioral principles but offers more flexibility than other behaviorally based methods. We examined the effectiveness of interteaching relative to a traditional form of classroom instruction-the lecture. In Study 1, participants in a graduate course in special education took short quizzes after alternating conditions of in...

Countering the use of biological agents (biothreats) requires a complex network of intelligence, detectors, laboratories, and the personnel and facilities to treat exposed individuals. In October 2009, 8 years after the mailing of letters containing Bacillus anthracis, the causative agent of anthrax, the Commission on the Prevention of Weapons of Mass Destruction Proliferation and Terrorism rel...

The activity of excitatory neurons is controlled by a small, but highly diverse population of inhibitory interneurons. These cells show a high level of physiological, morphological and neurochemical heterogeneity, and play highly specific roles in neuronal circuits. In the mammalian hippocampus, these are divided into 21 different subtypes of GABAergic interneurons based on their expression of ...