Withaferin A (WA) is a steroidal lactone purified from medicinal plant "Indian Winter Cherry" that is widely researched for its variety of properties, including antitumor effects. However, the primary molecular target of WA is unknown. By chemical structure analysis, we hypothesized that Withaferin A might be a natural proteasome inhibitor. Computational modeling studies consistently predict th...

Withaferin A (WA) isolated from Withania somnifera (Ashwagandha) has recently become an attractive phytochemical under investigation in various preclinical studies for treatment of different cancer types. In the present study, a comparative pathway-based transcriptome analysis was applied in epithelial-like MCF-7 and triple negative mesenchymal MDA-MB-231 breast cancer cells exposed to differen...

Original Article COMPARING FOUR ELECTRICAL STIMULATORS WITH DIFFERENT PULSES PROPERTIES AND THEIR EFFECT ON THE DISCOMFORT AND ELICITED DORSIFLEXION Gad Alon 1*, David G. Embrey 2, Brenna A. Brandsma 3, Jeff Stonestreet 4. 1* Associate Professor, Emeritus, University of Maryland, School of Medicine, Baltimore, MD 2 Research Program Coordinator, MultiCare Good Samaritan, Puyallup, WA and Clinica...

Pulsed high intensity focused ultrasound (pHIFU) enhances delivery of doxorubicin in a preclinical model of pancreatic cancer Tong Li, Yak-Nam Wang, Tatiana D. Khokhlova, Samantha D’Andrea, Frank Starr, Hong Chen, Jeannine S. McCune, Linda J. Risler, Afshin Mashadi-Hossein, Joo Ha Hwang 1 Center for Industrial and Medical Ultrasound, Applied Physics Laboratory, University of Washington, Seattle...

Envelope Detection (ED) is traditionally always used with Fast Fourier Transform (FFT) to identify the rolling element bearing faults. The inability of FFT to detect non-stationary signals makes Wavelet Analysis (WA) an alternative for machinery fault diagnosis as WA can detect both stationary and non-stationery signals. A comparative study of ED with FFT and WA techniques for bearing fault dia...

In this paper, two Japanese particles wa and mo are taken up. Wa is known as a topic marker and mo is a correspondent of English particles too and also. After reviewing several studies that claim topics and particles like too and also evoke alternatives, a formal semantic system with structured meanings is constructed for wa and mo, incorporating the insights of the previous studies. The propos...

The work of hospital food service is characterized by demands that can be associated with work ability--WA. The aim of this study was to evaluate factors associated with WA among hospital food service professionals and recommend intervention measures. This is a cross sectional study carried out in 2009, conducted in a hospital of São Paulo, Brazil. Participants were 76 (96.2%) of the eligible. ...

Withaferin A (WA), a major bioactive component of the Indian herb Withania somnifera, induces cell death (apoptosis/necrosis) in multiple types of tumor cells, but the molecular mechanism underlying this cytotoxicity remains elusive. We report here that 2 μM WA induced cell death selectively in androgen-insensitive PC-3 and DU-145 prostate adenocarcinoma cells, whereas its toxicity was less sev...