The pandemic of Coronavirus Disease 2019 (COVID-19) has now affected the entire globe which was first surfaced in China December 2019. In absence effective therapy to manage COVID-19, repurposed therapies were being used condition. view an urgent need for definitive therapy, multiple drugs, and investigational drug candidates are tried clinical trials may lead emergence unknown short term long ...

PURPOSE This study aimed to develop an algorithm for uncovering associations masked by extreme reporting rates, characterize the occurrence of masking by influential outliers in two spontaneous reporting databases and evaluate the impact of outlier removal on disproportionality analysis. METHODS We propose an algorithm that identifies influential outliers and carries out parallel analysis aft...

background although in many countries child abuse reporting is mandated, iranian nurses report abused cases voluntary. some of the cases are reported to the police and others are referred to welfare organizations or other non-governmental organizations. absence of a uniform reporting system along with a lack of legal support in the specific cultural context of iran has resulted challenges for t...

BACKGROUND Psychotropic medications are the mainstay of treatment in psychiatric disorders and are associated with ADRs which affect the compliance and treatment course. Previous studies have looked at the frequency, profile of ADRs and their management aspects. However, the systematic comparison between IP and OP was lacking even though there is a prescription pattern difference. Hence this st...

BackgroundPharmacovigilance is a critical component to facilitate clinicians’ decision-making alter or discontinue therapy. However, self-administration of oral targeted therapy (OTT) requires fewer clinical visits than parenteral infusions, potentially leading an increase in the under-reporting adverse drug reactions (ADRs).Objective(s)To identify factors associated with patients reporting ADR...

BACKGROUND Burden of adverse drug reactions (ADRs), in home-environment and domestic settings, is unknown. OBJECTIVE To discuss the epidemiology of reported ADRs to 13-Aban drug and poison information center (DPIC) and to discuss the burden of hospitalization caused by these ADRs from commonly implicated therapeutic groups. METHODS A retrospective analysis of the yellow card schemes of susp...

BACKGROUND Cough is listed as an adverse drug reaction (ADR) on the labels of angiotensin receptor blockers (ARB). However, a causal association with cough has also been reported for angiotensin converting enzyme inhibitors (ACEI), which have frequently been used as comparator drugs in the registration clinical trials of ARBs. This prompted us to examine the possible influence of using comparat...

Globally, adverse drug reactions (ADRs), one of the leading causes of morbidity and mortality, will continue to pose a threat to public health as long as drugs are being used to treat various ailments. Prompt ADR reporting is crucial in ensuring drug safety. The aim of this narrative review was to highlight the role of pharmacists in pharmacovigilance and to identify barriers and facilitators t...

For the safe use of medicinal products, it is important that physicians publish adverse experiences with a medicinal product-particularly regarding side effects-in the scientific literature. However, when searching applicable publications, we determined that adverse drug reactions (ADRs) are often published several months after their occurrence. In the context of patient safety, this is rather ...