Intrinsic skeletal muscle abnormalities decrease muscular endurance in chronic heart failure (CHF). In CHF patients, the number of skeletal muscle Na(+)-K(+) pumps that have a high affinity for ouabain (i.e., the concentration of [(3)H]ouabain binding sites) is reduced, and this reduction is correlated with peak oxygen uptake. The present investigation determined whether the concentration of sk...

Vital capacity (VC), forced expiratory volume in 1 s (FEV(1)), peak expiratory flow (PEF), mean forced expiratory flow (FEV(25-75)), and maximum voluntary volume (MVV) were measured in 36 girls and 36 boys with hearing loss and compared with the same number of normal healthy children, all subjects were aged 10-16 years. They participated in an exercise test to calculate VO(2 max) in order to de...

We here investigated the effect of bis(1-oxy-2-pyridinethiolato) oxovanadium (IV), [VO(OPT)], against myocardial hypertrophy and cardiac functional recovery in pressure overload-induced hypertrophy in ovariectomized female rats and defined mechanisms underlying its cardioprotective action. Wistar rats subjected to bilateral ovariectomy were further treated with abdominal aortic stenosis. VO(OPT...

The purpose of this study was to investigate the oxygen cost of running barefoot vs. running shod on the treadmill as well as overground. 10 healthy recreational runners, 5 male and 5 female, whose mean age was 23.8±3.39 volunteered to participate in the study. Subjects participated in 4 experimental conditions: 1) barefoot on treadmill, 2) shod on treadmill, 3) barefoot overground, and 4) shod...

The FTO gene has significant polymorphic variation associated with obesity, but its function is unknown. We screened a population of 150 whites (103F/47M) resident in NE Scotland, United Kingdom, for variants of the FTO gene and linked these to phenotypic variation in their energy expenditure (basal metabolic rate (BMR) and maximal oxygen consumption VO(2)max) and energy intake. There was no si...

OBJECTIVE Synchronised swimming is a sport that shares certain characteristics with other aesthetically pleasing sports such as gymnastics and dance. The purpose of this investigation was to ascertain whether the highest ranked synchronised swimmers in the United Kingdom experience menstrual abnormalities, a common medical problem seen in these related activities. METHODS Twenty three members...

The aim of this study was to evaluate the effect of a 15% increase in preferred pedal rate (PPR) on both time to exhaustion and pulmonary O(2) uptake (VO(2)) response during heavy exercise. Seven competitive cyclists underwent two constant-power tests (CPT) at a power output that theoretically requires 50% of the difference in VO(2) between the second ventilatory threshold and VO(2)max (Pdelta5...

Anthropometry is the single most portable, systemized technique, universally applicable, inexpensive, and noninvasive method available to assess the proportions, size, and composition of the human body. Maximum oxygen uptake (VO max) is internationally accepted parameter to evaluate the cardiorespiratory fitness. But determination of VO max is restricted within well equipped laboratory because ...

AIMS Chronotropic incompetence (CI) is a common finding in patients with advanced chronic heart failure (CHF) and is associated with a worse functional capacity. Whether rate responsive pacing with cardiac resynchronization therapy (CRT) would acutely improve exercise performance in patients with advanced CHF and severe CI (<70% age-predicted maximum heart rate) is unknown. METHODS AND RESULT...