Abstract Natural products are major molecules for drug discovery due to their structural diversity and interaction with various biological targets, yet clinical application is limited by poor water solubility or low lipophilicity, inappropriate molecular size, dissolution rate permeation, instability, high metabolic rapid clearance. These issues can be solved nanomedicine, improving bioavailabi...

The present study deals with the formulation, characterization of Metronidazole loaded ethosomal gel for treating oral infection. system comprises 2-5% phospholipids, 20-50% ethanol, 10% propylene glycol, cholesterol and v/v aqueous phase. Cold method was applied to develop ethosome. prepared ethosome evaluated vesicle size, entrapment efficiency,The Optimized Ethosome formulation converted in ...

Introduction: Etodolac is used in the treatment of acute pain and inflammation. It has low solubility because high hydrophobicity it reported that upon oral administration shows gastric disturbances. This encourages development topical vesicular formulation.
 Method: In this work we coacervation-phase separation method for etodolac loaded system by using non-ionic surfactants, cholesterol ...

BACKGROUND The purpose of this study was to investigate lecithin-chitosan nanoparticles as a topical delivery system for quercetin. METHODS Tocopheryl propylene glycol succinate was chosen to be the surfactant for the nanosystem. The mean particle size of the nanoparticles was 95.3 nm, and the entrapment efficiency and drug loading for quercetin were 48.5% and 2.45%, respectively. Topical del...

Nanoparticles that readily penetrate mucosal layers are desirable for a variety of biomedical applications. Nevertheless, most nanoparticles tend to be immobilized in mucus via steric and/or adhesive interactions. Contrary to the established opinion that poly(vinyl alcohol) (PVA) is mucoadhesive, we discovered that coating otherwise mucoadhesive nanoparticles with certain partially hydrolyzed P...

The main aim of the present research was to encapsulate mefenamic acid in niosomes andincorporate the prepared niosomes in the carbopol gel base for sustained therapeutic action. Mefenamic acid loaded niosomes were prepared by thin film hydration technique and evaluated for entrapment efficiency, vesicular size and zeta potential. The entrapment efficiency of the prepared niosomes was found to ...

Buccal bioadhesive bilayer tablets of prochlorperazine maleate were designed and formulated by using buccoadhesive polymers such as hydroxypropylmethyl cellulose, Carbopol 934P, and sodium alginate. Physicochemical characteristics like the uniformity of weight, hardness, thickness, surface pH, drug content, swelling index, microenvironment pH, in vitro drug release, and in vivo buccoadhesion ti...

The most superficial layer of the skin, the stratum corneum, is the major barrier for permeation of most drugs. In order to increase the efficiency of drugs delivered via the skin, there is a demand for new transdermal drug delivery systems. Over the last two decades vesicles have been explored as potential carriers for drugs with the aim to facilitate drug transport across the stratum corneum....

The objective of the present study was to formulate and evaluate a thermoreversible formulation containing rizatriptan benzoate for intranasal administration. Chitosan and aqueous β−glycerolphosphate were mixed in cold condition to obtain chitosan-β−glycerolphosphate mixtures, which served as the thermoreversible systems. Rizatriptan benzoate was incorporated at a fi nal strength of 25 mg/ml. B...

The goal of the current study was to explore the potential benefits of Acitretin (Act) nanovesicular gel as a prospective antipsoriatic topical delivery system counteracting the drug challenges in terms of its extremely low aqueous solubility, instability, skin irritation, and serious systemic adverse effects. Act-loaded niosomes were successfully developed, entirely characterized, and optimize...