Brief summary: This paper describes the pilot data for UK 100 000 Genomes Project, including Whole Genome Sequencing (WGS) on 4660 participants from 2183 families, and covering 161 disorders. They made a genetic diagnosis in 25% of probands; diagnoses were more likely probands who presented with intellectual disability, hearing, or visual disorders (range 40% to 55%) cases had WGS family trios ...

purpose: to evaluate the success rate of nd:yag laser membranotomy in patients with diabetic premacular hemorrhage. methods: this interventional case series included 24 eyes of 22 patients referred to retina clinic of farabi eye hospital, tehran, iran during 2000-2007 with chief complaint of sudden loss of vision and clinical diagnosis of premacular hemorrhage due to proliferative diabetic reti...

PURPOSE To investigate vision-related quality of life (VR-QOL) in patients undergoing vitrectomy for various vitreoretinal disorders and to evaluate the relationship between VR-QOL and visual function. METHODS The study included 100 normal control subjects and 299 patients with various vitreoretinal disorders including proliferative diabetic retinopathy (PDR), diabetic macular edema (DME), br...