The visceral leishmaniasis (VL) has a wide geographic distribution, with 90% of its occurrence concentrated in six countries: Bangladesh, Brazil, Ethiopia, India, South Sudan and Sudan. Dogs are the main reservoir in the VL transmission, not only for their close relationship and/or coexistence with men, but also for their immunological inability in responding to the disease successfully. For th...

Leishmania chagasi, the causative agent of visceral leishmaniasis (VL) in the Americas, has recently been associated with atypical cutaneous leishmaniasis (ACL) in Central America; however, little comprehensive information about this disease is available. Clinical, epidemiologic, and parasitologic characteristics of 252 ACL cases and 44 VL cases in Nicaragua were analyzed. Visceral leishmaniasi...

Background: Visceral leishmaniasis (VL) is an endemic disease in some parts of Iran. Many techniques have been used for diagnosis of VL, among which the urine based la-tex agglutination test (KAtex) is a promising one. Objective: To compare three diag-nostic tests of VL including KAtex, ELISA and Direct Agglutination Test (DAT) in VL patients and healthy controls in the south west of Iran. Meth...

Visceral leishmaniasis (VL) is considered one of the endemic diseases in Iraq, and due to distinction anti-leishmaniasis treatments currently used by their many side effects addition toxicity human body, as well length treatment period, problems they cause digestive system, Salvia officinalis (Saga) was a natural preventive against leishmaniasis. Because its therapeutic properties for health sy...

SETTING Two subdistricts in Bangladesh, Fulbaria and Trishal, which are hyperendemic for leishmaniasis. OBJECTIVE To determine 1) the numbers of patients diagnosed with visceral leishmaniasis (VL) and post-kala azar dermal leishmaniasis (PKDL) using an active case detection (ACD) strategy in Fulbaria and a passive case detection (PCD) strategy in Trishal, and 2) the time taken from symptoms t...

© 2014 The Authors. doi: 10.2340/00015555-1582 Journal Compilation © 2014 Acta Dermato-Venereologica. ISSN 0001-5555 Post-kala-azar dermal leishmaniasis (PKDL) is a recalcitrant dermatosis following apparent cure from visceral leishmaniasis (VL). Patients with PKDL are considered the sole reservoir for the parasite during inter-epidemic periods of VL in India (1). Mono-drug therapy has been rec...

BACKGROUND Visceral Leishmaniasis (VL) has worldwide distribution including Pakistan. The disease is characterized by a spectrum of clinical features along with serious complications in untreated cases. This study describes the correlation between clinical manifestations with haematological changes of VL in Hazara Division. METHODS This cross sectional study was carried out in the children wa...

Visceral leishmaniasis (VL) is endemic in Northwest and southern Iran. Reports of cutaneous leishmaniasis (CL) in Northwest areas are rare, and its etiological agents are unknown. In the current study, we report six CL and two post kala-azar dermal leishmaniasis (PKDL) cases caused by Leishmania infantum from endemic areas of VL in the Northwest. Smears were made from skin lesions of 30 suspect...

Visceral leishmaniasis (VL) is caused by various species of the genus Leishmania. Internalization of Leishmania into host cells is facilitated by a large number of receptors, and therefore no panacea is available for the treatment of leishmaniasis. We previously demonstrated the requirement of host membrane cholesterol in the entry of Leishmania into macrophages by cholesterol depletion using m...

The lymphocytes from eight patients with active visceral leishmaniasis (VL), a disease associated with marked immunologic dysfunction, were examined for ability to produce interleukin 2 (IL-2) and gamma interferon during in vitro cultivation. It was found that both IL-2 and gamma interferon production, in response to leishmania antigen, was absent during the active disease, but was restored aft...