نتایج جستجو برای: visceral gout
تعداد نتایج: 31438 فیلتر نتایج به سال:
Gout is a common metabolic disease but spinal gout is rare. We report a case of gouty arthritis affecting the thoracic spine in a 76-year-old male patient with a long history of tophaceous gout who presented with bilateral lower limb weakness. Magnetic resonance imaging of his thoracic spine revealed erosions in the left pedicles of T8 and T10. The initial imaging diagnosis was metastatic disea...
Gout is a common disorder characterized by chronic hyperuricemia and recurrent attacks of acute inflammatory arthritis, affecting approximately 1–3% of the population. Recently, gout has received increased attention partly owing to the development of new therapies (including the first approved gout treatment in more than 40 years) and an improved understanding of its pathophysiology. Recent res...
Gout affects 1% to 2% of the population, and the prevalence is increasing due to changes in diet and the ageing of the population. Its development and risk factors have been explored frequently, and recommendations for the diagnosis and management of gout implemented. Nevertheless, there is a lack of knowledge regarding the long-term impact on gouty patients. This systematic review therefore ev...
The definitive classification or diagnosis of gout normally relies upon the identification of MSU crystals in SF or from tophi. Where microscopic examination of SF is not available or is impractical, the best approach may differ depending upon the context. For many types of research, clinical classification criteria are necessary. The increasing prevalence of gout, advances in therapeutics and ...
Gout is a systemic, inf lammatory arthritis caused by deposition of monosodium urate (MSU) crystals within synovial or periarticular tissue. Currently, it is estimated to affect 6.1 million Americans [1,2]. The acute phase of gout manifests clinically as a monoarticular inflammatory arthritis, and can mimic a septic joint. Chronic gout is characterized by the formation of tophi, both intraosseo...
Deposition of crystallized monosodium urate (MSU) in joints as a result of hyperuricemia is a central risk factor for gout. However other factors must exist that control the progression from hyperuricaemia to gout. A previous genetic association study has implicated the toll-like receptor 4 (TLR4) which activates the NLRP3 inflammasome via the nuclear factor-κB signaling pathway upon stimulatio...
OBJECTIVE Gout, caused by hyperuricaemia, is a multifactorial disease. Although genome-wide association studies (GWASs) of gout have been reported, they included self-reported gout cases in which clinical information was insufficient. Therefore, the relationship between genetic variation and clinical subtypes of gout remains unclear. Here, we first performed a GWAS of clinically defined gout ca...
There is still debate on whether high uric acid increases bone mineral density (BMD) against osteoporotic fracture or bone resorption caused by gout inflammation. This study aimed to evaluate whether gout offers a protective effect on bone health or not. We conducted a nationwide population-based retrospective cohort study to evaluate the association between gout history and risk factors of fra...
OBJECTIVE Gout is a painful and disabling joint disease that constitutes the most common inflammatory arthritis in the US. To clarify the economic impact of gout, we systematically reviewed the literature on the direct and indirect costs associated with this disease. METHODS We conducted a literature search of MEDLINE, EMBASE, International Pharmaceutical Abstracts, NHS Economic Evaluation, a...
BACKGROUND Both gout and sleep apnoea are associated with the metabolic syndrome. Hyperuricaemia is also prevalent in sleep apnoea syndrome. The objective of this study was to examine the association between gout and sleep apnoea and other sleep disorders. METHODS Data were taken from a validated database of general practice records from nine practices in the UK between 2001 and 2008. People ...
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