نتایج جستجو برای: viral inactivation

تعداد نتایج: 197344  

Journal: :Clinical and diagnostic laboratory immunology 1997
T Preuss S Kamstrup N C Kyvsgaard P Nansen A Miller J C Lei

In order to compare protocols for inactivation of viruses potentially present in biological specimens, three different model viruses were treated in bovine serum by two different inactivation methods: samples were subjected either to chemical inactivation with ethylenimine (El) at concentrations of 5 and 10 mM at 37 degrees C for periods up to 72 h or to electron-beam irradiation in frozen and ...

2017
Mun-Teng Wong Steve S. Chen

In this study, we elucidated the mechanism by which human choline kinase-α (hCKα) interacts with nonstructural protein 5A (NS5A) and phosphatidylinositol-4-kinase IIIα (PI4KIIIα), the lipid kinase crucial for maintaining the integrity of virus-induced membranous webs, and modulates hepatitis C virus (HCV) replication. hCKα activity positively modulated phosphatidylinositol-4-phosphate (PI4P) le...

Journal: :journal of nanostructures 2014
s. sadeghi- kaji b. shareghi m. salavati

in this study the effects of fe2o3 and fe3o4 magnetic nanoparticles and edta on urease activity was investigated. the effect of nano-fe2o3 and nano-fe3o4 on urease activity were investigated. urease activity was studies by uv-vis spectrophotometry at 40 °c at ph = 7.2 using sodium phosphate as buffer. measurements were carried out using 0.075 mg/ml of urease and a range of nano-fe2o3 and nano-f...

Journal: :journal of paramedical sciences 0
bi bi fatemeh nobakht motlagh ghochani proteomics research center, faculty of paramedical sciences, shahid beheshti university of medical sciences, tehran seyedeh zahra moosavi-nejad department of biology, faculty of basic sciences, alzahra university, tehran seyed ashkan ordibehesht tehran sport medicine board, tehran

lysozyme is considered as part of the innate immune system. it has stimulated considerable interest as a natural food preservative. lysozyme has been shown to be effective in preserving a variety of foods such as fresh fruits and vegetables, meats, seafood and wine, for which many japanese patents have been granted. the relatively high thermal stability of lysozyme also makes it attractive for ...

Journal: :Development 2011
Anne-Valerie Gendrel Edith Heard

The third X-inactivation meeting 'Fifty years of X-inactivation research', which celebrated the fiftieth anniversary of Mary Lyon's formulation of the X-inactivation hypothesis, was an EMBO workshop held in Oxford, UK, in July 2011. This conference brought together the usual suspects from the field, as well as younger researchers, to discuss recent advances in X-inactivation research. Here, we ...

2007
A. KIRN

Purified vaccinia virus was irradiated by 7-rays under direct-effect conditions. The ability of the irradiated samples to form plaques (infectivity) and to induce viral DNA synthesis was determined. The radiosensitive volume of the viral unit causing infection (I.9 × IO-X7 cm2) is very small compared with the volume of the whole viral DNA ( ~ IO %). The inactivation of the DNA replication funct...

Dong Zhang, Hui Chen, Jiang Hua Ren Sheng Ping Chao

The goal of this study was to determine the effects of the L-type calcium channel blockers verapamil and diltiazem on the currents of voltage-gated potassium channel (fKv1.4ΔN), an N-terminal-deleted mutant of the ferret Kv1.4 potassium channel. Measurements were made using a two electrode voltage clamp technique with channels expressed stably in Xenopus oocytes. The fKv1.4ΔN currents displayed...

Journal: :Applied and environmental microbiology 1982
M E Alvarez R T O'Brien

Chlorine dioxide and iodine inactivated poliovirus more efficiently at pH 10.0 than at pH 6.0. Sedimentation analyses of viruses inactivated by chlorine dioxide and iodine at pH 10.9 showed that viral RNA separated from the capsids, resulting in the conversion of virions from 156S structures to 80S particles. The RNAs release from both chlorine dioxide- and iodine-inactivated viruses cosediment...

Journal: :Journal of biomedical optics 2009
Kong-Thon Tsen Shaw-Wei D Tsen Q Fu Stuart M Lindsay Karen Kibler Bert Jacobs T-C Wu B Karanam S Jagu Richard B S Roden Chien-Fu Hung Otto F Sankey B Ramakrishna Juliann G Kiang

We report a photonic approach for selective inactivation of viruses with a near-infrared subpicosecond laser. We demonstrate that this method can selectively inactivate viral particles ranging from nonpathogenic viruses such as the M13 bacteriophage and the tobacco mosaic virus to pathogenic viruses such as the human papillomavirus and the human immunodeficiency virus (HIV). At the same time, s...

2000
F. H. X. E. W.

Human plasma-derived protein concentrates intended for clinical use must be treated for viral inactivation to ensure patient safety. This study explored the use of liquid iodine for inactivation of several lipidand nonlipid-enveloped viruses in an antithrombin 111 (AT-Ill) concentrate. Iodine at levels of 0.01% to 0.02% caused between 43% and 94% loss of AT-Ill activity, as well as degradation ...

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