OBJECTIVES To summarise the current status of genital herpes simplex virus (HSV) vaccine development and provide a discussion of the potential benefits and limitations of genital herpes vaccines. METHODS Literature review. RESULTS Genital herpes simplex virus infection has a complex pathogenesis that has contributed to it becoming a serious worldwide problem. In an attempt to control the pr...

background: there is a controversy about the relation between anti-hepatitis b (anti-hbs) antibody level and obesity. we designed this study to compare the vaccine efficacy in obese/overweight and non-obese cases. methods: in this cross-sectional study, 242 obese/overweight and 85 non-obese individuals were participated. cases were selected from a referral clinic for obesity and a referral hepa...

background: health care workers (hcw) are at high risk of contracting various infectious diseases and play a dual role in the transmission of infections in health care facilities. objective: to determine the seroprotection against hepatitis b, measles, rubella, and varicella among hcws in a community hospital in qatar. methods: this is a cross-sectional survey conducted in a 75-bed community ho...

Recombinant viral subunit-based vaccines have gained increasing attention due to their enhanced safety over the classic live-attenuated or inactivated vaccines. The low immunogenicity of the subunit antigen alone, however, requires the addition of an adjuvant to induce immunity. Particulate-based delivery systems have great potential for developing new vaccine adjuvants, compared to traditional...

BACKGROUND Hepatitis C virus (HCV) genomic variability is a major challenge to the generation of a prophylactic vaccine. We have previously shown that HCV specific T-cell responses induced by a potent T-cell vaccine encoding a single strain subtype-1b immunogen target epitopes dominant in natural infection. However, corresponding viral regions are highly variable at a population level, with a r...

The liver being vulnerable to wide variety of metabolic, toxic, microbial, circulatory and neoplastic insults is subjected to potential damage resulting in acute or chronic hepatic disorders. Viral hepatitis has always been a disease of major concern. The existence of atleast five distinct viral hepatitis agents has been documented namely HAV, HBV, HCV, HDV and HEV. Distinctive differences in s...

This study explores the methodology of various experimental vaccines and their immunogenicity outcome in detail. The idea is to give to the reader a picture of the research methodology behind vaccine development that was used in this research. The novelty of this study bases on the demonstration of the cause and effect of antibodies produced against bacterial and viral proteins (immunogens) as ...

hbs vaccines were prepared by three different methods: 1) heat inactivation (krugman, et.al 1971)2) ammonium sulphate precipitation followed by column chromatography (sephadex g-200) 3) peg-6000 (polyethylene glycol) precipitation followed by column chromatography using sephadex g-200. their efficacy was studied in guinea pigs, and the results compared with commercial japanese vaccine (green cr...

background hepatitis b is the most common chronic viral infection in humans and the most common cause of death among viral hepatitis. as 70% to 80% of chronic hepatitis cases are caused by hbv in iran, this virus alone is considered the most important cause of liver diseases and the major cause of mortality arising from viral hepatitis cases in iran. objectives we planned this study to determin...