objective: the global hiv epidemic continues to expand and exceeding previous predictions. an effective vaccine represents the best hope to curtail the hiv epidemic. dna vaccines induce humoral and cellular responses and mimic live vaccines without their pathogenic potential. the importance of cd8+ ctl responses in controlling hiv and siv viremia has led to production of a series of vaccine can...

according to the reports of who, stability of rev.1 vaccine should take more than one year, while the expiring date for the vaccine produced in iran is 3 to 4 months, therefore any attempt to elongate the stability of this vaccine can solve many problems of the production including the request of veterinary organization of iran in this regard. the objective of this study was to increase the sta...

an inactivated trivalent fowl cholera vaccine consisted of serotypes 1, 3 and 4 pasteurella multocida strains was prepared. the vaccine provided 70-100% protection against challenge with homologous starins. elisa assay showed a considerable increase in antibody titer after towice vaccination of 8 weeks chickens. it was found that the trivalent vaccine can induce immunogenic response in vaccinat...

the use of liposome as an adjuvant and a vaccine carrier has been cited previously in the literature. it has also been shown to be effective in enhancing the immunogenicity of vaccine candidates. balb/c mice immunized subcutaneously with outer membrane protein (omp) of brucella abortus s19 vaccine strain entrapped in a commercial cationic liposome (s19-omp-liposome) for vaccine delivery, showed...

background: re-emergence of pertussis has been reported in iran despite a high rate of vaccination coverage. low efficacy of the vaccine might be due to the genetic divergence between clinical versus vaccine strains. in the current study, the genetic profiles of clinical isolates and vaccine strains of bordetella pertussis (b. pertussis) were assessed by using pulsed field gel electrophoresis (...

protection of animals immunized against bacillus anthracis is usually demonstrated by challenging with an appropriate dose of a strain of bacillus anthracis that is lethal to unvaccinated animals inoculated at the same time. in this study the protective efficacy in anthrax vaccine (34f2 sterne strain spore) was evaluated in sheep, goats and guinea pigs challenged with subcutaneous inoculation o...

a field trial was canied outon60 volunteers selected in yazd province, central iran, with a vaccine containing killed promastigotes of l. major prepared by the razi institute, hessarak. during these phase i studies which lasted for more than two years, we examined acceptable doses of the vaccine alone or mixed with bcg. the results so far indicate that 50 to 1000 µg of the vaccine alone can be ...

Introduction: Vaccination has been the most effective human intervention in alleviating human sufferings and death. Vaccine production in Iran has a long history however, in the face of a changing global landscape, it requires a new roadmap for research, development and production in the coming decades. Methods: This document was drafted based on Article A of the “Comprehensive National S...