Allylnitrile, cis-crotononitrile, and 3,3'-iminodipropionitrile are known to cause vestibular toxicity in rodents, and evidence is available indicating that cis-2-pentenenitrile shares this effect. We evaluated nineteen nitriles for vestibular toxicity in wild type (129S1) and CYP2E1-null mice, including all the above, several neurotoxic nitriles, and structurally similar nitriles. A new acute ...

BACKGROUND: Congenital cytomegalovirus (CMV) infection is the leading infectious cause of neurologic disabilities and sensorineural hearing loss in children. Sensorineural hearing loss prevalence in CMV suggests a viral tropism for the inner ear. Vestibular disorders induced by CMV infection are underestimated. This is the largest and most thorough study to assess the incidence of vestibular di...

OBJECTIVES To investigate head and shoulder alignment among patients with unilateral vestibular hypofunction (UVH), using computerized biophotogrammetry (CB) and to correlate these measurements with gender, age, duration of clinical evolution, self-perception of intensity of dizziness and occurrences of falls. METHODS This was a cross-sectional study. Thirty individuals with UVH and 30 with n...

Objectives/Hypothesis: Attention Deficit/Hyperactivity Disorder (ADHD) designates a spectrum of disorders characterized by inattention, impulsivity and hyperactivity whose neurological foundations are largely unknown. Current research hypothesizes several mechanisms for the symptoms seen in this heterogeneous population, including vestibular dysfhnction. Past research has investigated the vesti...

Since changes in vestibular function may be one cause of disequilibrium, major advances in measuring postural control and sensory integration in vestibular impairments have been achieved by using posturography. However, in order to overcome problems related to this type of technology, body-worn accelerometers (ACC) have been proposed as a portable, low-cost alternative to posturography for meas...

BACKGROUND AND PURPOSE Although several articles have been published on central vestibular syndrome mimicking acute peripheral vestibulopathy (ie, pseudo-acute peripheral vestibulopathy), there are no reports of a brainstem infarct that selectively involves the vestibular nucleus and causes isolated vertigo. SUMMARY OF CASE We report a patient with an isolated vestibular nucleus infarction wh...

OBJECTIVE: 1) To correlate caloric results with sinusoidal and step-velocity rotary chair gain, phase, asymmetry and time constant values in all patients; 2) To evaluate sensitivity, specificity, positive predictive value and negative predictive value of both tests in patients with vestibular dizziness. STUDY DESIGN: Retrospective case review. SETTING: Academic tertiary care vestibular function...