Venous leg ulceration is a severe complication of chronic venous insufficiency. Despite numerous studies, understanding of the possible mechanisms involved in venous ulceration development remains incomplete. It is assumed that, in addition to well-documented behavioral and/or environmental conditions, as yet poorly defined genetic risk factors may play important roles in chronic wound progress...

Introduction Managing venous leg ulcers presents challenges to the individuals who live with them and the healthcare providers participating in their care. Adding to the burden of every venous leg ulcer is the risk that it will recur after it has healed, an outcome which represents personal, social, financial and psychological costs to the individual and further economic burden to healthcare pr...

Venous leg ulcer (VLU) is a type of chronic wound that can take a long time to heal, being the most advanced presentation of chronic venous insufficiency (CVI).1 VLUs are usually recurrent, affecting work productivity, quality of life and high public health care treatment costs. It is estimated that VLUs affect up to 1% of the adult population.1 These chronic wounds are usually infected by a di...

Trophic leg ulcer is a major health problem affecting approximately 1-2% of the population, the incidence being higher in the elderly (70-80 years). It is a multifactorial condition, but the most common cause is chronic venous insufficiency. This can be attributed to reflux in the saphenous system and calf perforator vein incompetence. These were first described by Linton, the first interventio...

Dear Editors, Eccrine porocarcinoma (EPC) is a rare, malignant skin tumour arising from the ductal portion of eccrine sweat glands and was first described by Pinkus and Mehregan in 1963 (1). With a 20% rate of local recurrence and the potential to metastasize in regional lymph nodes in another 20% of cases (2), EPC often takes an aggressive clinical course (3). Organ spreading is only found occ...

The aim of this study was to compare five types of compression therapy in venous leg ulcers (intermittent pneumatic vs. stockings vs. multi layer vs. two layer short stretch bandages vs. Unna boots). Primary study endpoints were analysis of changes of the total ulcer surface area, volume and linear dimensions inside observed groups. The secondary end points were comparisons between all groups t...

Inflammatory changes within varicose veins can result in skin complications including venous leg ulcer (VLU). We have previously proposed that cytokines involved T cell activation are markers of disease and may be targets to attenuate progression. Here, we measured circulating from subjects with without ulcer. hypothesized associated interferon gamma (IFN-γ), IL-2, IL-12p70 would elevated vein ...