The Past In 1950, as a medical student, I first learned about the management of congestive HF from the first edition of Harrison’s Principles of Internal Medicine,1 which had just been published. Management consisted of strict bed rest, sedation, dietary sodium restriction, digitalis, venesection, and administration of morphine and mercurial diuretics; the latter were only modestly effective an...

Few data exist concerning possible infectious complications associated with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). The present prospective evaluation was undertaken in order to determine the incidence of bacteraemia and infectious complications associated with EBUS-TBNA. Consecutive patients undergoing EBUS-TBNA for evaluation of mediastinal or hilar lymph...

A competitive protein-binding assay for 25-hydroxy vitamin D (25-OHD) in saliva has been established by adaptation of that previously described for 25-OHD in serum (Fairney et al. 1979). Random values of salivary 25-OHD in patients attending hospital for venesection showed a wide range of results (105-1000 pg/ml, n 55). These values corresponded to 1.2% of the total serum values with which they...

The molecular basis for the recently described hereditary hyperferritinemia-cataract syndrome is the presence of a mutation in the iron-responsive element (IRE) of the L ferritin gene, located on chromosome 19q13.3-13.4. Two mutations have been reported so far, altering adjacent nucleotides in the IRE loop, in a region that has been extensively studied in vitro and shown to mediate high affinit...

The treatment of acute left ventricular failure by morphine and venesection frequently produces as dramatic relief of symptoms as does the intravenous administration of glucose in a case of insulin shock. Cases which have not responded to morphine alone may recover promptly after the removal of from 500 to 800 cc. of blood. Many clinicians (1, 2, 3, 4) believe that pooling of blood in the extre...

The fatty acid composition of bone marrow lipid was studied in 10 normal individuals and in 90 patients with a hematologic disorders. Simultaneously , the fatty acid composition of bone marrow was studied in rabbits and dogs which were injected with nitromin and cortisone, and others which were irradiated and subjected to periodic venesection. The fatty acid composition of normal human bone mar...

Objective MicroRNAs (miRNAs) may serve as potential biomarkers in a variety of pathologies. The aim of this study was to determine whether miRNAs could serve as blood-based markers of isolated coronary artery calcification (CAC) defined as CAC in the absence of an underlying metabolic abnormality. Methods 24 age-matched and sex-matched patients who had been referred for elective CT coronary c...

old man was referred to M o r r i s t o n Hospital in S e p t e m b e r 2012 with slurred speech and a two-week history of progressively reduced mobility. The man had been found in bed by his carers, unable to mobilise. In 1996 he was diagnosed with haemochromatosis, which had been treated with repeated venesection. He was diagnosed with Parkinson’s disease in 2002; however, this diagnosis was ...

OBJECTIVE The progression from impaired glucose tolerance (IGT)/impaired fasting glucose (IFG) to type 2 diabetes can be prevented or delayed through intensive lifestyle changes. How to translate this to implementation across whole communities remains unclear. We now describe the results to a pilot of a personal trainer (Maori Community Health Worker, MCHW) approach among Maori in New Zealand. ...