BACKGROUND The aim of this research was to develop a rat model for vascularized composite allotransplantation (VCA) of the elbow. METHODS We developed an animal model for VCA of the elbow in rats. Microvascular VCA was performed in 9 rats across a major histocompatibility barrier. Three different immunosuppressive regimens were provided. Joint mobility and weight-bearing capability were asses...

opportunistic infections are the leading cause of hospitalization and morbidity in human immunodeficiency virus (hiv) positive patients and are the most common cause of death between them. we aimed to measure igg antibody against ebv viral capsid antigen (ebv-vca igg) to determine the seroprevalence of this infection in hiv-positive population. a case-control study between september 2011 and oc...

conclusions considering the results, accurate and on time diagnosis of ebv primary infection in both children and adolescents will help prevent unnecessary hospitalization, medication and incorrect medical decisions. in addition, this will decrease further treatment costs and related medical procedures. background many children become infected with epstein-barr virus (ebv) during their childhoo...

Assessment of immunoglobulin A (IgA) antibody responses to various Epstein-Barr virus (EBV) antigen complexes, usually involving multiple serological assays, is important for the early diagnosis of nasopharyngeal carcinoma (NPC). Through combination of two synthetic peptides representing immunodominant epitopes of EBNA1 and viral capsid antigen (VCA)-p18 we developed a one-step sandwich enzyme-...

OBJECTIVES Elevated humoral responses to cytomegalovirus (CMV) associate with increased risk of cardiovascular disease (CVD) in HIV patients on antiretroviral therapy (ART). To better understand the persistence of CMV humoral responses in relation to CVD, we determined trends in CMV antibody levels over the first 10 years on ART. DESIGN We describe longitudinal analyses of plasma from 13 HIV ...

Recipients of solid organ transplants (RSOT) have a highly increased risk for developing cutaneous premalignant and malignant lesions, favored by the lifelong immunosuppression. Vascularized composite tissue allografts (VCA) have been introduced recently, and relevant data are sparse. Two patients with skin cancers (one with basal cell carcinoma and one with squamous cell carcinomas) have been ...

At the molecular level the plant cell walls consist of a few nanometer thick semi-crystalline cellulose fibrils embedded in amorphous matrix polymers such as pectins, hemicelluloses, and lignins. The arrangement of these molecules within the cell wall in different plant tissues, cells and cell wall layers is of crucial importance for a better understanding and thus optimized utilization of plan...

Mitral regurgitation (MR) is considered the most common valve disease with a prevalence of 2-3 % of significant regurgitation (moderate to severe and severe) in the general population. Accurate assessment of the severity of regurgitation was demonstrated to be of significant importance for patient management and prognosis and consequently has been widely recognized in recent guidelines. However...