Adenosine is a short-acting coronary vasodilator, and it is widely used during pharmacological stress myocardial perfusion imaging. It has a well-established safety profile, and most of its side effects are known to be mild and transient. Until now, coronary vasospasm has been rarely reported as a side effect of adenosine during or after adenosine stress test. This study reports a case of coron...

• Considerable evidence indicates that an adrenergic vasoconstrictor mechanism exists in the coronary vascular bed. In the classification advanced by Ahlquist,' the sites mediating this response are termed alpha receptors. Whether or not an adrenergic dilator mechanism exists also in the coronary vessels remains controversial, since it is unclear whether the decrease of coronary resistance that...

• Considerable evidence indicates that an adrenergic vasoconstrictor mechanism exists in the coronary vascular bed. In the classification advanced by Ahlquist,' the sites mediating this response are termed alpha receptors. Whether or not an adrenergic dilator mechanism exists also in the coronary vessels remains controversial, since it is unclear whether the decrease of coronary resistance that...

The past 10-15 years has been a time of focus on the mechanisms of control in the human cutaneous circulation. Methodological developments have provided powerful means for resolving the important contributors to the reflex control of skin blood flow (thermoregulatory control) and also for the equally impressive effects of direct heating and cooling of the skin (thermal control). This review is ...

We investigated the distinct ability of various antihypertensive drugs to modulate the extent (%) of rapid (15 minutes) resetting of the baroreceptors of normotensive rats to hypotensive levels. In one protocol, hemorrhage produced a complete resetting to hypotension in rats chronically treated (6 days) with captopril. Also, hemorrhage produced only partial resetting in rats acutely treated (10...

Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by an elevated pulmonary arterial pressure and vascular resistance with a poor prognosis. Various pulmonary and extrapulmonary causes are now recognized to exist separately from the idiopathic form of pulmonary hypertension. An imbalance in the presence of vasoconstrictors and vasodilators plays an important role ...

Although the outlook for a pronounced improvement in the ischaemic limb that cannot be surgically treated remains bleak, cessation of smoking, encouragement of exercise, and the withdrawal of vasoconstricting agents may give some symptomatic relief. There is little evidence that vasodilators or antiplatelet agents have much to offer.

Using an accurately calibrated flowmeter in the descending thoracic aorta of the dog, a study was made of alterations in aortic flow patterns following intravenous and intra-arterial injections of vasoactive drugs. When injected distal to the flowmeter, vasopressors caused marked backflow while vasodilators raised the level of the lowest portion of the pulsatile flow curve. When injected into t...

Femomi blood flow and arterial pressure l-esponses to stimulation of the lumbar sympathetic chain at L3, L4 and L5 were compared with i-esponses to intm-arterial injections of 1-epinephrine and 1-norepinephrine before and after progressively increasing levels of adrenergic blockade, and after atropine. The vasoconstrictor i-esponses to nerve stimulation resembled most closely those caused by 1-...

Atrial fibrillation (AF) is a common rhythm in patients with acute decompensated heart failure (ADHF). Registry and trial data1,2 indicate that 20% to 35% of patients with ADHF who are admitted to the hospital will be in AF at presentation. In about one third of these patients, the AF will be of recent onset. Despite the high frequency with which the combination of AF and ADHF is encountered, t...