Background: Cerebral vasospasm is a major cause of morbidity and mortality in patients with subarachnoid hemorrhage. Vasospasm managed triple H vasodilators but sometimes, do not respond. Intra-arterial vasodilator infusion has been shown to improve outcome such patients. In this study, we try evaluate the efficacy intra-arterial nimodipine therapy 43 post-aneurysmal hemorrhage refractory cereb...

The purpose of the work presented here was to investigate endotheliumdependent relaxations in the rabbit coronary ligation model of heart failure. We investigated endothelium-dependent relaxations at the level of larger vessels (thoracic aorta and vena cava left renal artery and left renal vein lateral saphenous artery and lateral saphenous vein and finally central ear artery and marginal e...

Regional cerebral blood flow (bicompartmental and stochastic method) was measured in a series of 20 patients with unilateral brain softening. Measurements were repeated during the administration of a vasodilator. A deterimental effect on the perfusion of the disease area was observed in the majority of cases. It has been shown that the chances for a vasodilator to decrease the perfusion in the ...

Renal microvascular disease is crucial to renal disease progression. Renal microvascular disease in late stage diabetic nephropathy is associated with defective angiogenesis and fails to respond to vasodilator treatment. Recognition of early renal microvascular disease is necessary, since in this stage, the vascular homeostasis is adequately functional and responsive to vasodilator treatment. I...

Background With the expanding use of vasodilator stress CMR, there has been a parallel rise in the use of regadenoson as a pharmacological stress agent. To date, however, prognostic data for stress CMR has focused on the use of adenosine or dipyridamole while prognostic data regarding the use of regadenoson is limited. We therefore sought to identify the prognostic value of regadenoson vasodila...

itric oxide (NO) is released by endothelial cells in response to hemodynamic forces (eg, shear stress, axial strain) and has vasodilator and anti-atherogenic properties. Endothelial dysfunction is associated with diminished bioavailability of NO and poor prognosis in patients with traditional cardiovascular risk factors. Rather than directly measuring NO concentrations, most previous studies ha...

To assess factors responsible for phasic behavior of renal blood flow in essential hypertension, we applied an analytic method based on the estimation of power spectral density to xenon transit through the kidney and examined the renal vasodilator response to a range of agents in 53 normal subjects and 53 patients with essential hypertension. The renal vasodilator response to the calcium channe...