Pulmonary arterial hypertension (PAH) is characterized by progressive obliteration of the pulmonary vascular bed leading to increased right ventricular afterload, right heart failure, and death. PAH is now regarded as a disease caused mainly by pulmonary vascular remodeling rather than by abnormal pulmonary vasoconstriction. Histopathological hallmarks are proliferation of endothelial cells, ab...

With cardiovascular diseases being among the main causes of death in the world, quantitative modeling, assessment and monitoring of cardiovascular dynamics, and functioning play a critical role in bringing important breakthroughs to cardiovascular care. Quantification of cardiovascular physiology and its control mechanisms from physiological recordings, by use of mathematical models and algorit...

The main objective of this work is to develop machine learning models for the prediction of patient outcome in nephrology care as well as to validate and optimize the models with a feature selection approach. Cardiovascular events are a major cause of morbidity and mortality in hemodialysis (HD) patients and have an incidence of 20% in the first year of renal replacement therapy. Real data rout...

Hedgehog (Hh) proteins belong to a class of morphogens involved in many biological processes during embry-onic development; they are relatively silent during normal adult life although they may be recruited postnatally in re-sponse to tissue injury. Three secreted proteins have been identified: Sonic hedgehog (Shh), Desert hedgehog and Indianhedgehog. The interaction of Hh ligand wi...