AIMS To report a case of an unusual retinal vascular morphology in connection with a novel AIPL1 mutation in a patient with Leber's congenital amaurosis (LCA). METHODS A patient with LCA and no light perception from birth had both eyes enucleated at the age of 22 years because of excruciating pain. Mutation analysis was performed on known LCA genes. The eyes were processed for casts of the va...

The connection between architecture and science and sound based on mathematical relations has continued to develop[ since the rise of the Western classical civilization that originated in Ancient Greece. The mysterious Pythagorean cosmology pursued as secret esoteric knowledge was related to the search of rhythm, proportionality and harmony. Even somewhat earlier, Greek mysteries were based on ...

The CM-2 is an example of a connection machine. The strengths and problems of this implementation are considered. Then important issues in the architecture and programming environment of connection machines in general are considered. These are contrasted with the same issues in MD multiprocessors and multicomputers.

At this conference many interesting talks were presented on the plausible existence of Quark Stars. Other talks dealt with the exotic new phases of quark matter at very high density. Here, I show how combining these two elements might offer a new way of tackling the Gamma Ray Burst puzzle.

In this issue of Arteriosclerosis, Thrombosis, and Vascular Biology, Awan and coworkers1 describe the study of 25 homozygous familial hypercholesterolemic (FH) patients aged 5 to 54 years. Eighteen of the patients had aortic calcification scores 1000. The inference of this study is a strong linkage between homozygous FH and premature aortic calcification. Bazan et al2 have recently described th...

PURPOSE Vascular access device fragment embolization is a relatively rare but potentially serious complication. The purpose of this study was to report our experience with endovascular retrieval of embolized vascular access device fragments by interventional radiological means. MATERIALS AND METHODS Ten patients with a vascular access device fragment embolism were treated between 2004 and 201...

Computations in geographic space are necessarily based on discrete versions of space, but much of the existing work on the foundations of GIS assumes a continuous infinitely divisible space. This is true both of quantitative approaches, using R, and qualitative approaches using systems such as the Region-Connection Calculus (RCC). This paper shows how the RCC can be modified so as to permit dis...

Abstract Introduction Cardiovascular disease is an independent contributor to cognitive impairment. With imminent rise in chronic cardiovascular disease, a better understanding of its effects on brain health warranted. Impaired blood flow the one main hypothesized mechanisms linking with abnormal aging. Purpose To investigate relations between (subclinical) cardiac dysfunction and vascular inju...