abstract: introduction & objective: helicobacter pylori are among the important pathogens responsible for chronic gastritis, peptic ulcer and gastric cancer. the present study aimed to comparatively evaluate pcr and rut methods for detection of h. pylori and determination of the prevalence of the cagapositive helicobacter pylori strains in shahrekord. materials & methods: this is a molecular ep...

conclusions about 90% of h. pylori strains potentially contained vaca s2m2 and s1m2 genotypes. infection with h. pylori strain containing the caga gene or the vaca s1m1 and s1m2 genotypes was associated with increased incidence of peptic ulcer disease (pud). objectives the aim of this study was to determine the frequency of two toxins and genotypes of vaca toxin in patients referred to a centra...

background and objective: helicobacter pylori has several strains with different degrees of virulence. the aim of this study was to detect two major important virulence factors, caga/vaca genotypes, and to determine correlations among different caga/vaca genotypes and histological features of chronic gastritis in iranian patients. methods: in this cross- sectional study, gastric biopsy was take...

Infection with Helicobacter pylori is a major risk factor for chronic atrophic gastritis (CAG), a precursor lesion of intestinal gastric cancer. The pathogenicity of the bacterium is thought to play an important role in determining the extent and severity of clinical outcome. We aimed to assess the associations between CAG and the serostatus of antibodies to 15 H. pylori proteins. The analyses ...

BACKGROUND Helicobacter pylori (H. pylori) infection is known as a major etiologic factor for a variety of gastroduodenal diseases. In Iran, with a high rate of H. pylori infection close to 90%, numerous studies have revealed many aspects of interaction between the bacterium, mucosal surface and induction of disease outcome. The organism is genetically diverse and several virulence factors are ...

background : data concerning the information on the prevalence and association of the helicobacter pylori cytotoxinassociated gene a (caga) with disease is still controversial. the aim of this study was to isolate and identify h. pylori by culture methode from biopsy specimens and its relationship with associated diseases by molecular techniques (pcr). materials and methods: gastric biopsy spec...

Helicobacter pylori causes cellular vacuolation in host cells, a cytotoxic event attributed to vacuolating cytotoxin (VacA) and the presence of permeant weak bases such as ammonia. We report here the role of γ-glutamyl transpeptidase (GGT), a constitutively expressed secretory enzyme of H. pylori, in potentiating VacA-dependent vacuolation formation in H. pylori-infected AGS and primary gastric...

Short nucleotide sequence inserts within the signal (s) and mid (m) regions of the vacuolating cytotoxin gene (vacA) of Helicobacter pylori provide the basis for defining the allelic forms widely used for strain typing and as markers for toxin functionality and severity of interactions with host gastric epithelial cells. Here 484 signal region and 411 mid-region sequences (new and from public d...

Helicobacter pylori (H. pylori) infection is associated with gastritis and marked infiltration of the gastric mucosa by several cytokines secreting inflammatory cells. Different clinical forms of the infection may reflect distinctive patterns of cytokine expression. Interleukin (IL)-17, IL-21, IL-22, and IL-23 have been reported to be involved in H. pylori-induced gastric mucosal inflammation, ...