Riboflavin-UVA photodynamic inactivation is a potential treatment alternative in therapy resistant infectious keratitis. The purpose of our study was to determine the impact of riboflavin-UVA photodynamic inactivation on viability, apoptosis and activation of human keratocytes in vitro. Primary human keratocytes were isolated from human corneal buttons and cultured in DMEM/Ham's F12 medium supp...

Solar radiation is an important risk factor for skin cancer, the incidence of which is increasing, especially in the fair-skinned populations of the world. While the ultraviolet (UV)B component has direct DNA damaging ability, UVA-induced effects are currently mainly attributed to the production of reactive oxygen species. In our recent study, we compared the effects of UVA and UVB radiation on...

We measured the attenuation of ultraviolet B (UVB) and ultraviolet A (UVA) radiation in 32 streams located within the Ontonagon River watershed on the Upper Peninsula of Michigan, USA. Attenuation coefficients (Kd) of UVB and UVA ranged widely among these streams, but generally translated into relatively shallow 1% transmission depths into the water column (2–45 cm for UVB and 6–103 cm for UVA)...

Solar UV radiation is the most important environmental factor involved in the pathogenesis of skin cancers. The well known genotoxic properties of UVB radiation (290-320 nm) mostly involve bipyrimidine DNA photoproducts. In contrast, the contribution of more-abundant UVA radiation (320-400 nm) that are not directly absorbed by DNA remains poorly understood in skin. Using a highly accurate and q...

We investigated the photomutagenicity of maltol (3-hydroxy-2-methyl-4H-pyran-4-one) in bacterial cells. Maltol has a caramel-butterscotch odour and is used as a food additive to impart flavour to bread and cakes. Unirradiated maltol was not mutagenic up to 5 mg/plate in the Ames test. When maltol was irradiated with either UVA (a black light, 320-400 nm, 230 microW/cm(2)) for 5-30 min or UVC (a...

Organisms living on the earth are exposed to solar radiation, including its ultraviolet (UV) components (for general reviews, the reader is referred to Smith [1] and Young et al. [2]). UV wavelength regions present in sunlight are frequently designated as UVB (290-320 nm) and UVA (320-400 rim). In today’s solar spectrum, UVA is the principal UV component, with UVB present at much lower levels. ...

Adult skin stem cells are considered an attractive cell resource for therapeutic potential in aged skin. We previously reported that multipotent human dermal stem/progenitor cells (hDSPCs) can be enriched from (normal human dermal fibroblasts (NHDFs) using collagen type IV. However, the beneficial effects of hDSPCs on aged skin remain to be elucidated. In the present study, we analyzed the grow...

• Enhanced bacteria inactivation at low water temperature by UVA- and solar-based AOPs. Mechanism of suggested. Preliminary cost estimation AOPs was performed. Carbon footprint in Spain Finland compared. In this work the effect (6 ± 1 °C 22 °C) on (10 4 –10 6 CFU mL ?1 ; Pseudomonas spp. , Aeromonas spp . Enterobacter spp.) simulated aquaculture streams (SAS) using UVA based advanced oxidation ...

OBJECTIVE Treatment of patients with systemic lupus erythematosus (SLE) often implies strong drugs with possibly serious side effects. Thus there is a need for new immunosuppressive treatments. Long wave ultraviolet A (UVA-1) cold light therapy is an anti-inflammatory, immunomodulatory treatment with a possible systemic effect and few side effects. In the current study low dose UVA-1 cold light...