OBJECTIVE To compare the effects of vaginal hysterectomy (combined with anterior and/or posterior colporraphy) and abdominal sacro-colpopexy (with preservation of the uterus) on urogenital function. DESIGN Randomised trial. SETTING Three teaching hospitals in The Netherlands. POPULATION Eighty-two patients undergoing surgical correction of uterine prolapse stages II-IV. METHODS Particip...

PURPOSE Pelvic organ prolapse is a multifactorial disorder in which extracellular matrix defects are implicated. Fibrillin-1 level is reduced in stress urinary incontinence. In Marfan syndrome, which is associated with mutations in Fibrillin-1, pelvic floor disorders are commonly observed. We hypothesize that Fibrillin-1 gene expression is altered in pelvic organ prolapse. METHODS Thirty wome...

Spina bifida, or spinal dysraphism, is a malformative pathology related to an anomaly in the development of nervous system, occurring during embryogenesis. The neural tube does not close properly around 28th day life and affects column cord. bifida characterised by damage system will generate handicaps varying degrees: neurological motor, sensory, cognitive, genito-phincter (bladder anorectal) ...

The purpose of this study is to evaluate the expression of hypoxia-inducible factor-1α (HIF-1α) in women uterosacral ligament tissues with pelvic organ prolapse and women with normal uterine support structures and illuminate its relationship with apoptosis. Samples were collected from 38 women with pelvic organ prolapse and 31 age matched controls. The expression levels of HIF-1α and BNIP3 in t...

The present project was planned to conduct an epidemiological survey of genital prolapse in buffaloes kept under different feeding and production systems and to study serum micro mineral contents in these animals. Data on 343 buffaloes were recorded for epidemiological studies, including 297 normal pregnant and 46 prolapsed cases. For serum micro mineral contents, blood samples were collected f...

PURPOSE This study aimed to investigate the surgical outcomes and safety of robotic sacrocolpopexy (RSC) in patients with uterine/vaginal vault prolapse. METHODS Between January 2009 and June 2015, 16 women with apical prolapse underwent RSC. Pelvic organ prolapse quantification (POP-Q) examination was performed, and treatment success was defined as the presence of grade 0 or I apical prolaps...