One part of the human placenta in early pregnancy is particularly important for local immunity: the decidua basalis, which is transformed endometrium located at the site of embryo implantation . This placental bed tissue contains both maternal uterine immune cells, including decidual natural killer (NK) cells, the dominant leukocyte population exhibiting a unique phenotype, and fetal extravillo...

BACKGROUND: Indonesia has numerous coal resources, but the effects of environmental pollution by dust to human health, especially reproductive system, are still less investigated. Chronic exposures during pregnancy might cause systemic and uterine inflammation that induces disturbances spiral artery remodeling. AIM: This research was conducted analyze effect remodeling natural killer (NK) cell ...

Background and objectives:Scrophularia variegata M. Beib. (Scrophulariaceae) is a medicinal plant, used for various inflammatory diseases in Iranian Traditional Medicine. In the present study, we evaluated the immune modulation and antioxidant effects of the hydroalcoholic extract of S.  variegata. Methods: The splenocytes were harvested...

Precursors of uterine NK cells home to the uterus during early pregnancy from multiple lymphohemopoietic sources. In mouse uterine tissue, pregnancy markedly up-regulates both L-selectin- and alpha(4) integrin-dependent adhesion pathways for circulating human CD56(bright) cells, the phenotype of human uterine NK cells. Based on roles for these adhesion molecules in lymphocyte homing, we examine...

background: umbilical cord blood (ucb) is an alternative source of hematopoietic stem cell transplantation (hsct), used in leukemia treatment. cd26+ cells, a fraction of cd34 positive cells, are a major population of ucb cells which negatively regulate the in vivo homing and engraftment of hscs. cd26 is highly expressed in various cells such as hscs, immune cells, fibroblasts, and epithelial ce...

Background Natural killer (NK) cells are immune that can detect and eliminate tumor bridge innate to adaptive responses. Tumor specific activation of NK is thus an area active investigation in oncology, but date has relied on complex biologic modalities (e.g., antibodies, fusion proteins, or cell therapies), each which inherent disadvantages this application. Thus, alternative approaches warran...

Familial hemophagocytic lymphohistiocytosis (FHLH) with Epstein–Barr virus (EBV) infection can mimic chronic active EBV of T- and NK-cell type (CAEBV-T/NK) in its clinical manifestation pathomorphology. FHLH genetic susceptibility to has not been previously reported. The development conjunction is rare needs further investigation understand characterize it. We report a case that mimicked CAEBV-...