An 84-year-old gentleman presented with onset of gross hematuria in September 2010. Follow-up investigations revealed T1 superficially invasive, poorly differentiated, papillary urothelial carcinoma. He subsequently had GreenLight laser for BPH and bladder neck contracture on two occasions. He developed a right hydrocele 16 months after initial presentation and during his hydrocelectomy, a rock...

Urothelial carcinoma is well known for its divergent differentiation. Several "variant" morphologies have been described in the literature in recent years and have additionally been recognized in the recent World Health Organization classification of urothelial neoplasms. The importance of recognizing these variant histologies lies in the potential diagnostic, prognostic, or therapeutic implica...

Micropapillary variant of urothelial carcinoma (MPUC) is an uncommon variant of urothelial carcinoma with high metastatic potential. The cases reported in the literature were associated with high grade and advanced stages of the disease at presentation and had a poor prognosis. Four patients were diagnosed with MPUC at our center. One patient had an MPUC located in the urinary bladder, and the ...

Urothelial carcinoma in a few cases may result in cardiac metastasis. A rare presentation of this condition is its diagnosis as a result of cardiac tamponade. Tamponade is an unusual entity as a result of urothelial carcinoma and has only been reported in four cases. There have also been only a total of fifteen cases of cardiac metastasis from this form of malignancy. It is through this discuss...

INTRODUCTION Urinary bladder cancer patients who have undergone transurethral resection of bladder tumor (TURBT) are at risk of recurrence. This study aims to correlate the level of bone morphogenetic protein (BMP) expression with urothelial carcinoma invasiveness, TNM stage and time to recurrence after TURBT. MATERIAL AND METHODS In 33 specimens of healthy transitional epithelium and 42 of u...

Urothelial carcinoma is the fifth most common malignancy diagnosed each year in the United States. Neoadjuvant and adjuvant chemotherapy are given to decrease the risk of recurrent or metastatic disease with the more robust clinical data supporting the former. Bladder preservation utilizes a trimodality approach with maximal transurethral resection followed by concurrent chemotherapy and radiat...

A 58-year-old man presented with dysuria and microscopic hematuria. Biopsy revealed plasmacytoid urothelial carcinoma, a rare and aggressive form of bladder carcinoma with HER2 protein overexpression.

The incidence for bladder urothelial carcinoma, a common malignancy of the urinary tract, is about three times higher in men than in women. Although this gender difference has been primarily attributed to differential exposures, it is likely that underlying biologic causes contribute to the gender inequality. In this study, we report a transgenic mouse bladder tumor model upon induction of cons...

Muscle-invasive urothelial carcinomas of the bladder (MIUCB) exhibit frequent receptor tyrosine kinase alterations, but the precise nature of their contributions to tumor pathophysiology is unclear. Using mutant HRAS (HRAS*) as an oncogenic prototype, we obtained evidence in transgenic mice that RTK/RAS pathway activation in urothelial cells causes hyperplasia that neither progresses to frank c...

1Department of Pathology, College of Medicine, National Cheng Kung University, No.1 University Road, Tainan City 701, Taiwan 2Leeds Institute for Molecular Medicine, Section of Experimental Oncology, Cancer Research UK Clinical Centre, St Jame’s University Hospital, Beckett Street, Leeds LS9 7TF, UK 3 Johns Hopkins Medical Institutions, The James Buchanan Brady Urological Institute, 600 N. Wolf...