Photometric observations of V597 Pup made in 2008, 9.1 mag below maximum, 4 months after eruption, showed no certain orbital modulation but exhibited a quintuplet of oscillations centred on a period 261.9 s and uniform splitting at a frequency ∼ 2.68 h. One year later the system had fallen in brightness by a further 2.5 mag, showed deep eclipses with a period of 2.6687 h, and the 261.9 s modula...

C-type inactivation in the HERG channel is unique among voltage-gated K channels in having extremely fast kinetics and strong voltage sensitivity. This suggests that HERG may have a unique outer mouth structure (where conformational changes underlie C-type inactivation), and/or a unique communication between the outer mouth and the voltage sensor. We use cysteine-scanning mutagenesis and thiol-...

Trastuzumab is a growth-inhibitory humanized Ab targeting the oncogenic protein HER-2/neu. Although trastuzumab is approved for treatment of advanced breast cancer, a number of concerns exist with passive immunotherapy. Treatment is expensive and has a limited duration of action, necessitating repeated administrations of the mAb. Active immunotherapy with conformational B cell epitopes affords ...

In a recent issue of the JCMM, Sfrent-Cornateanu et al. [1] described an association between the G/A single nucleotide polymorphism (SNP) in the position -597 of the IL-6 gene, with disease activity and disability, but not with the disease per se, in 20 systemic sclerosis (SSc) patients.The idea of a disease-modifying, -rather than a disease-susceptibility, point mutation is intriguing and in l...

Keloid scars, which are excessive forms of cutaneous scarring, overgrow the boundaries original wound and do not regress spontaneously. Although keloid pathogenesis has been linked to numerous dysregulated signalling pathways, underlying causes remain poorly understood. scars have shown be 10-50 times stiffer than normal skin often form in areas body where tension is high. As a result, it thoug...

CD200R is an immune receptor of the IgG family that primarily expressed on cells myeloid lineage and was recently identified as a marker for Th2 biology (Blom et al 2017). In vivo studies with knockout mice either or its ligand, CD200, have demonstrated it inhibitory capable negatively regulating responses. Previous work using agonistic antibodies to mouse showed inhibition mast cell activation...

We investigated the relationships between single nucleotide polymorphisms (SNPs) of the interleukin (IL)-6 gene 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) and coronary artery disease (CAD) risk in a Chinese population. This case-control study recruited 296 CAD patients and 327 controls between January 2009 and May 2012. Genotyping of IL-6 174 G>C (rs1800795), 572 G>C (rs1...

BACKGROUND Pro-inflammatory cytokine gene polymorphisms are potential candidates for susceptibility for both type 2 diabetes mellitus (DM) and chronic periodontitis (CHP). This study explored the association of interleukin-1 beta (IL-1 β) +3954, interleukin-6 (IL-6) -597/-174 and tumor necrosis factor-alpha (TNF-α) -308 single nucleotide polymorphisms in CHP with and without type 2 DM in Malaya...