The intracellular distribution of sphingosine (Sph) kinase activity was examined in human platelets. A large proportion (72%) of the total activity was found to be associated with the membrane fraction, and the membrane-associated fraction had higher specific activity compared with the cytosolic enzyme. Most of the membrane-associated activity could be extracted with 1 M NaCl. The cytosolic act...

OBJECTIVES To measure circulating levels of oxidized-low-density lipoproteins (ox-LDL) in patients with stable and unstable angina and controls, and to investigate their correlation with the extent of coronary artery disease (CAD) and the presence of complex plaques at coronary angiography. METHODS AND RESULTS Circulating ox-LDL were assessed, using ELISA, in patients with unstable angina (UA...

We extend Schwede’s work on the unstable global homotopy theory of orthogonal spaces and L-spaces to the category of ∗-modules (i.e., unstable S-modules). We prove a theorem which transports model structures and their properties from L-spaces to ∗-modules and show that the resulting global model structure for ∗-modules is monoidally Quillen equivalent to that of orthogonal spaces. As a conseque...

In this paper, I argue that George Eliot's “Brother Jacob” (1864) reveals a fluid system of racial production is inextricably tied to sugar. one most unusual narratives. It written in the tone fable, and it concerns confectioner David Faux, who immigrates colony Jamaica. Twice, Faux's plans for fiscal gain are thwarted by his “idiot” brother, Jacob, latter's uncontrollable sweet tooth ways warn...

Motivated by mirror symmetry, we consider a Lagrangian fibration X → B and Lagrangian maps f : L →֒ X → B, when L has dimension 2, exhibiting an unstable singularity, and study how their caustic changes, in a neighbourhood of the unstable singularity, when slightly perturbed. The integral curves of ∇fx, for x ∈ B, where fx(y) = f(y)−x ·y, called “gradient lines”, are then introduced, and a study...

The medicinal properties of Cornus mas L. (=Cornus mascula L.), Cornaceae, are well described in Hippocratian documents, and recent research provides experimental evidence for some of these properties. However, the chemical components of Cornus mas L. that may be of pharmaceutical importance are relatively unstable. In this respect a novel methodology for plant nutrient element extraction that ...

Dehydro-L-ascorbic acid, the oxidation product of L-ascorbic acid, is unstable in aqueous solution and decomposed by a hydrolytic disruption of its ring structure to 2,3-diketo-L-gulonic acid. It is shown by means of UV, 'H-, and 13C-NMR spectroscopy that after decarboxylation 3,4,5-trihydroxy-2-keto-L-valeraldehyde, an a-ketoaldehyde, is formed. This substance is oxidized further to L-erythroa...

Unexpected complex of jumping lines We prove here the following results : Theorem 1 Let E a rank 2 vector bundle over P3, if C is a reduced irreducible curve of P3 such that EH is unstable for all H ∈ C then C is a line. We define now the set W (E) as the set of planes H such that the restricted bundle EH is unstable (that means non semi-stable). Theorem 2 Let E a rank 2 vector bundle over P3, ...