The within-litter relationship of fetal weight to fetal serum albumin and alpha-fetoprotein (AFP) was investigated at d 30 to 40, 45 to 50, 50 to 60, 75 to 85 and 90 to 105 of gestation in swine. Regression equations were calculated on individual litters and regression coefficients pooled across litters within each gestational age group. Coefficients for the regression of albumin on fetal weigh...

BACKGROUND The effects of oophorectomy on brain aging remain uncertain. METHODS We conducted a cohort study with long-term follow-up of women in Olmsted County, Minn., USA, who underwent either unilateral or bilateral oophorectomy before the onset of menopause from 1950 through 1987. Each member of the oophorectomy cohort was matched by age to a referent woman from the same population who had...

Women with type 1 diabetes have a delayed menarche and a greater prevalence of menstrual disorders than women without diabetes. However, little is known about the menopause transition among type 1 diabetic women. The Familial Autoimmune and Diabetes (FAD) Study recruited both adult individuals who were identified from the Children's Hospital of Pittsburgh Type 1 Diabetes Registry for the years ...

BACKGROUND The long-term cognitive effects of hysterectomy and oophorectomy remain controversial. OBJECTIVE To explore the association of hysterectomy and oophorectomy with the subsequent risk of cognitive impairment or dementia. METHODS We combined the results from two cohort studies graphically and conducted additional analyses. RESULTS Combined results from the Mayo Clinic Cohort Study...

OBJECTIVE To prospectively estimate the risk for earlier ovarian failure among women undergoing hysterectomy with ovarian preservation, as compared with women of similar age without hysterectomy. METHODS A prospective cohort study was conducted among women aged 30 to 47 years undergoing hysterectomy without bilateral oophorectomy (n=406) and women with intact uteri (n=465). Blood samples and ...

This study was conducted with random samples of pigs of a line (LS) selected for eight generations for litter size and a randomly selected control line (RS) in the Nebraska Gene Pool population and of crosses of these lines with a Large White-Landrace composite line (I) that was selected for an index of ovulation rate and embryonic survival to 50 d of gestation. Two experiments were done to obt...

The effects of high-sodium (HS) and normal-sodium (NS) diets on ovarian hormone modulation of mean arterial pressure (MAP) were examined in Dahl salt-resistant (DR) and salt-sensitive (DS) rats. Ovariectomy increased MAP (OVX-Sham) to a greater extent in DS rats maintained for 2 wk on a HS (22 mmHg) compared with a NS (6 mmHg) diet. Ovariectomy had no effect on MAP in DR rats on NS but did incr...

Postmenopausal estrogen deficiency increases the incidence of cerebrovascular disease. However, hormone replacement therapy is associated with an increased cardiovascular risk. Tamoxifen is a selective estrogen receptor modulator with estrogenic effects on cardiovascular risk factors, but its long-term impacts on cerebral vasculature are unknown. We hypothesized that chronic 17beta-estradiol or...

Breast cancer probably consists of a spectrum of diseases in terms of its hormonal dependence, as evidenced by the responses of patients to endocrine therapy. It is generally assumed that hormone-dependent breast cancers, which me spond to ovariectomy, would also respond to antiestrogen therapy. Studies in humans indicate a good correlation be tween the presence of estrogen receptor and respons...

HYPOTHESIS The selective estrogen receptor modulator raloxifene hydrochloride inhibits intimal hyperplasia. DESIGN Controlled laboratory experiment. SETTING Experimental animal model. INTERVENTION AND MAIN OUTCOME MEASURES Forty-three senile female sheep were randomized to sham operation, ovariectomy, or ovariectomy followed by treatment with 17beta-estradiol or raloxifene. Six months aft...