A new titanosaur dinosaur, Brasilotitan nemophagus gen. et sp. nov., is described from the Adamantina Formation (Turonian-Santonian, Bauru Basin). The specimen consists of a dentary, cervical and sacral vertebrae, one ungual and remains of the pelvic region, that were collected near Presidente Prudente city, Sdo Paulo State. It shows a mandible with an 'L' shaped morphology, with the symphyseal...

This work aimed to (a) characterize the microstructure and porosity of human nail and bovine hoof by mercury intrusion porosimetry and SEM image analysis, (b) study the effects of hydration and of N-acetyl-l-cysteine treatment on the microstructure of both membranes, and (c) determine whether the microstructural modifications were associated with changes in drug penetration measured by standard...

The soft tissue preserved in the holotype (IVPP V12705) of Jeholopterus ningchengensis from the Daohugou Bed (Late Jurassic or Early Cretaceous) of China is described in detail. The plagiopatagium can be divided into the distal, comparatively more rigid actinopagatium and a proximal, more tensile tenopatagium. The actinopatagium extends from the wing finger to the articulation between the humer...

Individuals with tuberous sclerosis complex (TSC) develop tumors in multiple organs due to pathogenic variants TSC1 or TSC2, skin showing mTOR activation and aberrant cell growth. To identify transcriptional signatures dysregulated signaling pathways that are shared different types of TSC tumors, we performed RNAseq on 58 samples fibroblast-like cells grown from (27 angiofibromas, 11 fibrous ce...

Background and Objectives: Photoaging ?1 is clinically characterized by irregular pigmentation (freckling, lentigines, persistent hyperpigmentation), dryness/roughness, telangiectasia, wrinkling, elastosis, and inelasticity. Currently available medical literature documents using intense pulsed light (IPL) 3 to 5 times to achieve satisfactory improvement. Study Design/Materials and Methods: Twen...

Phototoxic and photoallergic reactions represent skin reactions to the sun, in the presence of photoactive chemicals applied on the skin or taken systemically. They have a highly polymorphic clinical presentation – photo contact urticaria, eczema on sun-exposed areas sometimes with erythema multiforme, exaggerated sunburn, linear phytophotodermatitis, pseudoporphyria, photoonycholysis, dyschrom...

The aging process causes a number of changes in the skin, including oxidative stress and dyschromia. The kojic acid (KA) is iron chelator employed in treatment of skin aging, and inhibits tyrosinase, promotes depigmentation. Nanotechnology-based drug delivery systems, such as liquid crystalline systems (LCSs), can modulate drug permeation through the skin and improve the drug activity. This stu...

In Italy the economic crisis has caused changes in behavior in daily as well as leisure activities. For instance, night clubs have changed both their scenography and what they can offer. From simply providing a place to dance, they can now offer more complex scenography with spectacular fireworks and lit cocktails. While this can be amazing for all of us it can also be another cause of burn inj...

BACKGROUND A 1,927-nm wavelength was recently added to the 1,550-nm erbium-doped fiber laser. This wavelength possesses a higher absorption coefficient for water than the 1,550-nm, conferring greater ability to target epidermal processes such as dyschromia. OBJECTIVE To evaluate the efficacy and safety of a novel 1,927-nm fractional thulium fiber laser in the treatment of melasma. METHODS F...