BACKGROUND Unconjugated bilirubin (UCB) plays a protective role in coronary artery disease. Red cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are inflammatory biomarkers and higher levels are related to atherosclerosis and adverse cardiovascular events. AIM We aimed to investigate the relation between UCB levels and RDW, NLR, PLR in...

OBJECTIVES Umbilical cord blood-derived mesenchymal stromal cells (UCB-MSCs) are ideally suited for use in various cell-based therapies. We investigated a novel induction protocol (NIP) to improve the neuronal differentiation of human UCB-MSCs under appropriate conditions. MATERIALS AND METHODS This experimental study was performed in Iranian Blood Transfusion Organization (IBTO), Tehran, Ira...

Introduction Brain distribution of synaptic vesicle protein 2A was measured with fluorine-18 UCB-H ([18F]UCB-H) and positron emission tomography (PET). Methods Images of synaptic density were acquired in healthy volunteers (two young participants and two seniors). Input function was measured by arterial blood sampling (arterial input function) and derived from PET images using carotid activit...

We consider the sequential Bayesian op-timization problem with bandit feedback,adopting a formulation that allows for the re-ward function to vary with time. We modelthe reward function using a Gaussian pro-cess whose evolution obeys a simple Markovmodel. We introduce two natural extensionsof the classical Gaussian process upper confi-dence bound (GP-UCB) algorit...

Objective To study the safety and effect of the umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) on apoptosis of human cardiomyocytes (HCM). Methods UCB was collected at the time of delivery with informed consent obtained from 10 donors. The UCB-derived MSCs were treated with 5-azaserube (5-AZA) and were further induced to differentiate into cardiomyocytes. Telomerase activity, ...

BACKGROUND Lower incidence and severity of acute graft versus host disease (GVHD) has been observed in leukemia patients receiving HLA-mismatched umbilical cord (UCB) transplants. However, despite the increased use of UCB in stem cell transplantation, the mechanisms underlying these favorable outcomes are not well delineated. METHODS We analyzed antigen specific lymphocyte responses after tra...

The aim of this study was to quantify the palatal change in three groups of children: children with a unilateral posterior crossbite (TCB) who were treated, children with untreated unilateral posterior crossbite (UCB), and children without a crossbite (NCB). Study casts of 60 Caucasian children in the primary dentition (20 TCB, 20 UCB, and 20 NCB), aged 5.4 ± 0.7 years, were collected at baseli...

Vacuolar myelinopathy (VM) is a neurologic disease primarily found in birds that occurs when wildlife ingest submerged aquatic vegetation colonized by an uncharacterized toxin-producing cyanobacterium (hereafter "UCB" for "uncharacterized cyanobacterium"). Turtles are among the closest extant relatives of birds and many species directly and/or indirectly consume aquatic vegetation. However, it ...

BACKGROUND Jaundice is one of the most common problems encountered in newborn infants, due to immaturity of hepatic conjugation and transport processes for bilirubin. Although the majority of neonatal jaundice is benign, some neonates with severe hyperbilirubinemia develop bilirubin encephalopathy or kernicterus. Accumulation of unconjugated bilirubin (UCB) in selected brain regions may result ...

Upper tract urothelial carcinomas (UTUCs) consist of 5%-10% of all urothelial carcinomas, the rest being urothelial carcinomas of the bladder (UCB). There is increasing evidence to show that UTUC is a distinct disease entity from UCB based on phenotypical and genotypical (genetic and epigenetic) differences. This may account for why the natural history of UTUC is different from that of UCB, wit...