introduction: malignant astrocytic gliomas are the most common and lethal brain malignancies due to their refractory to the current therapies. nowadays, molecular targeted therapy has attracted great attention in treatment of glioma. connexin 43 (cx43) and micro ribonucleic acid- 21(mir-21) are among molecules that are involved in glioma development and progression. these molecules showed poten...

Background: Glioma is the most common primary brain tumor with poor prognosis. Temozolomide (TMZ) has been used with irradiation (IR) to treat gliomas. The aim of the present study was to evaluate the cytotoxic and radiosensitizing effect of TMZ when combined with high-dose and high-dose rate of gamma irradiation in vitro.Methods: Two ‘U87MG’ cell lines and skin fibroblast were cultured and ass...

A Comparative Study of the Cytotoxicity and DNAdamaging Effects of cÃ-s-(D¡ammino)(1,1-cyclobutanedicarboxylato)-platinum(ll) and c/s-Diamminedichloroplatinum(ll) on L1210 Cells. Kenneth C. Micetich, Diane Barnes and Leonard C. Erickson. Continued *4048 Inhibitory Effects of Dìpyrìdamele on Growth, Nucleoside Incorporation, and Platelet-activating Capability in the U87MG and SKNMC Human Tumo...

Introduction: One mechanism of cell cycle manipulation and mitotic catastrophe is arrest at G2/M phase of cell cycle. Cabazitaxel, a mitotic inhibitor agent, is a second-generation semisynthetic taxane. An expected anti-neoplastic effect of Cabazitaxel is cell cycle perturbation and alteration of microtubule dynamics. In contrast to other taxane compounds, Cabazitaxel is a poo...