Signaling by Notch family receptors is involved in many cell-fate decisions during development. Several modifiers of Notch activity have been identified, suggesting that regulation of Notch signaling is complex. In a genetic screen for modifiers of Notch activity, we identified a gene encoding a novel WD40-repeat protein. The gene is called Notchless, because loss-of-function mutant alleles dom...

Polycarbonate (PC) has a wide range of applications in the electronic, transportation, and biomedical industries. In addition, investigation on applicability to use PC superstrate photovoltaic modules is ongoing research. this paper, envisioned be used as material for structural components renewable energy systems. Usually, have geometrical irregularities, i.e., notches, are subjected severe me...

The Notch signalling pathway regulates cell fate choices during both vertebrate and invertebrate development. In the Drosophila wing disc, the activation of Notch by its ligands Delta and Serrate is required to make the dorsoventral boundary, where several genes, such as wingless and cut, are expressed in a 2- to 4-cell-wide domain. The interactions between Notch and its ligands are modulated b...

Rugate designs for the realization of notch filters are well known in the literature. The required deposition of gradient index layers is difficult to manufacture. In our approach we apply the equivalent index theory to replace the gradient index profile of a notch filter design. We produce single and multiple notch filters with plasma ion-assisted deposition and broad-band optical monitoring. ...

The proteolytic activity of Furin responsible for processing full length Notch-1 (p300) plays a critical role in Notch signaling. The amplitude and duration of Notch activity can be regulated at various points in the pathway, but there has been no report regarding regulation of the Notch-1-Furin interaction, despite its importance. In the present study, we found that the Notch-1-Furin interacti...

Notch signaling is critically important for proper architecture of the vascular system, and mutations in NOTCH3 are associated with CADASIL, a stroke and dementia syndrome with vascular smooth muscle cell (VSMC) dysfunction. In this report, we link Notch signaling to platelet-derived growth factor (PDGF) signaling, a key determinant of VSMC biology, and show that PDGF receptor (PDGFR)-beta is a...

PURPOSE Notch signaling is an important mediator of growth and survival in several cancer types, with Notch pathway genes functioning as oncogenes or tumor suppressors in different cancers. However, the role of Notch in osteosarcoma is unknown. EXPERIMENTAL DESIGN We assessed the expression of Notch pathway genes in human osteosarcoma cell lines and patient samples. We then used pharmacologic...

Notch signaling is known to play important roles during retinal development. Recently, Notch signaling has been shown to be active in proliferating Müller glia in acutely damaged chick retina (Hayes et al., 2007). However, the roles of Notch in mature, undamaged retina remain unknown. Thus, the purpose of this study was to determine the role of the Notch-signaling pathway in the postnatal retin...

A retransmission chipless tag with multiple U-shaped slot resonators is proposed to cut down the cost of traditional tags chips. Multiple side-by-side structures different lengths are printed on microstrip line, and two terminals line connected correspondingly orthogonal ultra-wideband (UWB) transceiver antennas form tag. The resonator has high Q values narrow impedance bandwidth. bandwidth tha...

The notch gene family encodes transmembrane receptors that regulate cell differentiation by interacting with surface ligands on adjacent cells. Previously, we demonstrated that tumor necrosis factor-alpha (TNF) induces neuroendocrine (NE) cell differentiation in H82, but not H526, undifferentiated small cell lung carcinoma lines. We now test the hypothesis that TNF mediates NE cell differentiat...