AIMS To evaluate the maintenance of efficacy and safety of insulin glargine 300 U/ml (Gla-300) versus glargine 100 U/ml (Gla-100) in people with type 2 diabetes mellitus (T2DM) using basal plus meal-time insulin for 12 months in the EDITION 1 trial. METHODS EDITION 1 was a multicentre, randomized, open-label, two-arm, phase IIIa study. Participants completing the initial 6-month treatment per...

— We consider the Klein-Gordon equation (KG) on a Riemannian surface M ∂ t u−∆u−mu+ u = 0, p ∈ N, (t, x) ∈ R×M, which is globally well-posed in the energy space. Viewed as a first order Hamiltonian system in the variables (u, v ≡ ∂tu), the associated flow lets invariant the two dimensional space of (u, v) independent of x. It turns out that in this invariant space, there is a homoclinic orbit t...

OBJECTIVE To describe the clinical experience and the pharmacokinetics of U-500 regular insulin in severely insulin-resistant obese type 2 diabetic patients. RESEARCH DESIGN AND METHODS Patients requiring >200 units of insulin with A1C levels >8.0% were switched to U-500 regular insulin. For the pharmacokinetic study, fasting subjects received 100 units of U-500 regular insulin subcutaneously...

— We consider the Klein-Gordon equation (KG) on a Riemannian surface M ∂ t u−∆u−mu+ u = 0, p ∈ N, (t, x) ∈ R×M, which is globally well-posed in the energy space. Viewed as a first order Hamiltonian system in the variables (u, v ≡ ∂tu), the associated flow lets invariant the two dimensional space of (u, v) independent of x. It turns out that in this invariant space, there is a homoclinic orbit t...

Background: Data shows vanadium protects pancreatic beta cells (BC) from diabetic animals. Whether this effect is direct or through the relief of glucose toxicity is not clear. This study evaluated the potential effect of oral vanadyl sulfate (vanadium) on glycemic status and pancreatic BC of normal and diabetic rats. Methods: Rats were divided into five groups of normal and diabetic. Diabetes ...

M. R. Alfarra, D. Paulsen, M. Gysel, A. A. Garforth, J. Dommen, A. S. H. Prévôt, D. R. Worsnop, U. Baltensperger, and H. Coe Laboratory of Atmospheric Chemistry, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland School of Earth, Atmospheric and Environmental Sciences, The University of Manchester, P.O. Box 88, Manchester M60 1QD, UK School of Chemical Engineering and Analytical Sciences, T...